Seifi Sharareh, Fakhrai Ghazal, Esfahani-Monfared Zahra, Khosravi Adnan, Abedini Atefeh, Salimi Babak, Seifi Maryam, Tabarraee Mahdi, Dehghani Ghorbi Mahmoud
Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Science, Tehran, Iran.
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Science, Tehran, Iran.
Tanaffos. 2023 Apr;22(4):411-417.
Lung cancer is the leading cause of cancer death. Among different lung cancer histopathologies, small cell lung cancer (SCLC) has been known to be the most aggressive and lethal nature. This study analyzed the epidemiological characteristics, outcomes, and trends of SCLC at a tertiary cancer care center in Iran.
Retrospectively collected demographic characteristics and survival outcome data on histologically proven SCLC patients during 2009-2019 at the National Research Institute of Tuberculosis and Lung Disease (NRITLD) were reviewed.
In a study of 334 SCLC patients, there were more male patients than female, with a ratio of 2.5 to 1, and the mean age at diagnosis was 58.36 years. While gender distribution and smoking status among women remained consistent over the study period, there was a significant increase in male smokers (P<0.001). Female patients were diagnosed at younger age and had a significantly lower proportion of smokers compared to males (P<0.016). The mean and median overall survival were 10.9 and 8.2 months, with one-, two-, and three-year survival rates of 21%, 10%, and 3% respectively. Younger patients and females had significantly higher survival rates. In both uni/multivariate analyses, only age < 58 years and female gender were significantly associated with longer survival.
The relatively unchanged trend of SCLC in our series suggests that further research on prevention strategies especially smoking cessation, early detection, and new treatment options is urgently required.
肺癌是癌症死亡的主要原因。在不同的肺癌组织病理学类型中，小细胞肺癌（SCLC）被认为具有最具侵袭性和致命性。本研究分析了伊朗一家三级癌症护理中心小细胞肺癌的流行病学特征、治疗结果及趋势。
回顾性收集了2009年至2019年期间在国家结核病和肺部疾病研究所（NRITLD）经组织学证实的小细胞肺癌患者的人口统计学特征和生存结局数据。
在一项对334例小细胞肺癌患者的研究中，男性患者多于女性，比例为2.5比1，诊断时的平均年龄为58.36岁。在研究期间，女性的性别分布和吸烟状况保持一致，但男性吸烟者显著增加（P<0.001）。与男性相比，女性患者诊断时年龄更小，吸烟者比例显著更低（P<0.016）。总生存的均值和中位数分别为10.9个月和8.2个月，1年、2年和3年生存率分别为21%、10%和3%。年轻患者和女性的生存率显著更高。在单因素/多因素分析中，只有年龄<58岁和女性与更长的生存期显著相关。
我们系列研究中小细胞肺癌相对不变的趋势表明，迫切需要对预防策略进行进一步研究，尤其是戒烟、早期检测和新的治疗选择。
