Lichtenthal P R, Rossi E C, Louis G, Rehnberg K A, Wade L D, Michaelis L L, Fung H L, Patrignani P
Anesth Analg. 1985 Jan;64(1):30-3.
The effects of intravenous nitroglycerin (NTG) upon the bleeding time, platelet aggregation response, and plasma 6-keto-PGF1 alpha concentration were measured in 17 patients about to undergo coronary bypass grafting. NTG produced a dose-related prolongation of the bleeding time that correlated with the accompanying decrease in systolic blood pressure. Platelet aggregation was not affected and measurements of 6-keto-PGF1 alpha failed to reveal detectable levels (less than 10 pg/ml) either before or after NTG infusion. This suggests that the prolonged bleeding time associated with NTG infusion may be due to vasodilation and increased venous capacitance, rather than altered vascular-platelet interaction.
对17例即将接受冠状动脉搭桥手术的患者，测定了静脉注射硝酸甘油（NTG）对出血时间、血小板聚集反应及血浆6-酮-前列腺素F1α浓度的影响。NTG使出血时间呈剂量依赖性延长，且与收缩压随之降低相关。血小板聚集未受影响，在输注NTG前后，6-酮-前列腺素F1α的测量均未发现可检测水平（低于10 pg/ml）。这表明，与输注NTG相关的出血时间延长可能是由于血管舒张和静脉容量增加，而非血管-血小板相互作用改变所致。
