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氯氮平预防使用通便剂的决策支持警报。

A Decision Support Alert for Promoting Prophylactic Laxative Use with Clozapine.

机构信息

Department of Medicine, University of Otago, Christchurch, New Zealand.

Department of Psychological Medicine, University of Otago, Wellington, New Zealand.

出版信息

Stud Health Technol Inform. 2024 Aug 22;316:1748-1749. doi: 10.3233/SHTI240766.

DOI:10.3233/SHTI240766
PMID:39176552
Abstract

We investigated the effectiveness of a decision support alert to improve prophylactic laxative use with clozapine in hospital. Prescribing data for first clozapine and laxative prescriptions were extracted and linked. Proportions of first clozapine prescriptions for which a laxative was co-prescribed within 24 hours was compared before and after alert implementation. The alert was associated with increased and earlier laxative co-prescribing.

摘要

我们研究了决策支持警报在改善氯氮平在院期间预防性使用缓泻剂方面的效果。提取并链接了氯氮平和缓泻剂的首诊处方数据。比较了警报实施前后 24 小时内同时开具缓泻剂的首诊氯氮平处方的比例。该警报与缓泻剂的更早、更多联合开具有关。

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引用本文的文献

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Clozapine-induced gastrointestinal hypomotility: UK pharmacovigilance reports, 2018-2022.氯氮平引起的胃肠道动力减退:英国药物警戒报告,2018 - 2022年
BJPsych Open. 2025 Mar 31;11(3):e79. doi: 10.1192/bjo.2025.29.