Deng Shaowen, Li Zhongyan, Yuan Lin, Shen Jie, Zeng Huaqiang
College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.
College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan 425100, China.
Nano Lett. 2024 Sep 4;24(35):10750-10758. doi: 10.1021/acs.nanolett.4c01884. Epub 2024 Aug 23.
Membrane-active molecular machines represent a recently emerging, yet important line of expansion in the field of artificial transmembrane transporters. Their hitherto demonstrated limited types (molecular swing, ion fishers, shuttlers, rotors, etc.) certainly call for new inspiring developments. Here, we report a very first motorized ion-transporting carrier-type transporter, i.e., a modularly tunable, light-powered propeller-like transporter derived from Feringa's molecular motor for consistently boosting transmembrane ion transport under continuous UV light irradiation. Based on the EC values, the molecular propeller-mediated ion transport activities under UV light irradiation for 300 s are 2.31, 1.74, 2.29, 2.80, and 2.92 times those values obtained without irradiation for Li, Na, K, Rb, and Cs ions, respectively, with EC value as low as 0.71 mol % for K ion under light irradiation.
膜活性分子机器是人工跨膜转运体领域中最近新兴但很重要的一个扩展方向。它们目前已展示出的类型有限（分子摆动器、离子捕获器、穿梭器、转子等），这无疑需要新的鼓舞人心的进展。在此，我们报道了首个机动化的离子转运载体型转运体，即一种模块化可调谐、光驱动的螺旋桨状转运体，它源自费林加分子马达，用于在连续紫外光照射下持续增强跨膜离子转运。基于EC值，在紫外光照射300秒下，分子螺旋桨介导的锂离子、钠离子、钾离子、铷离子和铯离子的转运活性分别是未照射时的2.31倍、1.74倍、2.29倍、2.80倍和2.92倍，其中钾离子在光照下的EC值低至0.71 mol%。
