微 RNA-221 表达水平升高和微 RNA-451 表达水平降低与甲状腺乳头状癌患者的不良预后相关。

Higher microRNA-221 and lower microRNA-451 expression are associated with poor prognosis in patients with thyroid papillary carcinoma.

机构信息

Medical College of Yangzhou University. Xuyi Clinical College. Department of General Surgery. Yangzhou. China..

出版信息

An Sist Sanit Navar. 2024 Aug 23;47(2):e1086. doi: 10.23938/ASSN.1086.

DOI:10.23938/ASSN.1086

PMID:39177218

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11410297/

Abstract

BACKGROUND

To analyze the relationship between serum microRNA-221 and microRNA-451 expression and the pathological features and prognosis of patients with thyroid papillary carcinoma.

METHODS

Cross-sectional study that included 120 patients with papillary thyroid cancer treated at the hospital and 120 healthy volunteers selected as the control group who underwent physical examination. The relative expression levels of microRNA-221 and microRNA-451 were compared between the thyroid papillary carcinoma group (prior to treatment) and the control group. Additionally, microRNA-221 and microRNA-451 expression levels were analyzed in patients with papillary thyroid carcinoma across different pathological characteristics.

RESULTS

Serum microRNA-221 relative levels were significantly higher (p<0.001) in the papillary carcinoma group compared to the control group, while microRNA-451 levels were higher in the control group (p<0.001). In the papillary carcinoma group, microRNA-221 expression was significantly higher in patients with extracapsular invasion (p<0.001), lymphatic metastasis (p=0.003), and poor prognosis (p<0.001). Conversely, microRNA-451 expression was significantly lower (p<0.001) in patients with extracapsular invasion, lymphatic metastasis and poor prognosis. In the multivariate logistic regression analysis, morphological features suggestive of an aggressive clinical behavior (extracapsular invasion and lymphatic metastasis) were related to high expression of microRNA-221 and low expression of microRNA-451 in patients with thyroid papillary carcinoma (p<0.001).

CONCLUSIONS

Serum microRNA-221 and microRNA-451 expression levels are significantly higher and lower, respectively, in patients with papillary thyroid carcinoma, particularly in patients with morphological features suggestive of an aggressive clinical behavior (extracapsular invasion and lymphatic metastasis) and, therefore, of a poor prognosis.

摘要

背景

分析血清 microRNA-221 和 microRNA-451 表达与甲状腺乳头状癌患者病理特征及预后的关系。

方法

采用病例对照研究，选取医院收治的 120 例甲状腺乳头状癌患者（治疗前）为病例组，同期体检的 120 例健康志愿者为对照组，比较两组间 microRNA-221 和 microRNA-451 的相对表达水平，分析甲状腺乳头状癌患者不同病理特征间 microRNA-221 和 microRNA-451 的表达水平。

结果

病例组血清 microRNA-221 相对水平显著高于对照组（p<0.001），microRNA-451 水平则显著低于对照组（p<0.001）。在病例组中，包膜外侵犯（p<0.001）、淋巴结转移（p=0.003）和预后不良（p<0.001）患者的 microRNA-221 表达显著更高，而 microRNA-451 表达则显著更低。多因素 logistic 回归分析显示，具有侵袭性临床行为特征（包膜外侵犯和淋巴结转移）的形态学特征与甲状腺乳头状癌患者 microRNA-221 高表达和 microRNA-451 低表达相关（p<0.001）。