ADA Forsyth Institute, Cambridge, Massachusetts, USA.
Department of Fundamental Sciences, Faculty of Dentistry, Bursa Uludag University, Bursa, Turkey.
Periodontol 2000. 2024 Oct;96(1):229-249. doi: 10.1111/prd.12603. Epub 2024 Aug 23.
Chronic inflammation poses challenges to effective cancer treatment. Although anti-inflammatory therapies have shown short-term benefits, their long-term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro-resolving mediators, which play a role in modulating the cancer microenvironment by promoting the resolution of initiated inflammatory processes and restoring tissue hemostasis. This review addresses current insights into how inflammation contributes to cancer pathogenesis and explores recent strategies to resolve inflammation associated with cancer.
慢性炎症对有效的癌症治疗构成挑战。尽管抗炎疗法显示出短期益处，但它们的长期影响可能并不理想，因为它们无法引发必要的炎症反应。最近的研究强调了专门的促解决介质的前景，这些介质通过促进启动的炎症过程的解决和恢复组织止血来调节癌症微环境。这篇综述讨论了目前对炎症如何促进癌症发病机制的认识，并探讨了最近解决与癌症相关炎症的策略。
