Peng A-Jian, Tang Xue, Jiang Gu-Fen, Zhou Xing
The First Clinical College of Traditional Chinese Medicine， Hunan University of Chinese Medicine， Changsha, Hunan 410007, China.
The First Affiliated Hospital of Hunan University of Chinese Medicine， Changsha, Hunan 410007, China.
Zhonghua Nan Ke Xue. 2024 Feb;30(2):174-179.
Ferroptosis is an iron-dependent form of programmed cell death triggered by the excessive accumulation of lipid peroxides on the cell membrane. Recent studies have found that ferroptosis can be induced by exposure of the testis tissue and germ cells to some high-risk factors, accompanied by various characteristic reproductive system injuries, including changes in cell morphology, ferroptosis-related physicochemical indicators and gene expressions. This review focuses on the association of ferroptosis with male reproductive system diseases from three key aspects: iron metabolism abnormalities, Cystine/GSH/GPX4 axis imbalance, and lipid peroxidation.
铁死亡是一种由细胞膜上脂质过氧化物过度积累引发的铁依赖性程序性细胞死亡形式。最近的研究发现，睾丸组织和生殖细胞暴露于某些高危因素可诱导铁死亡，并伴有各种特征性的生殖系统损伤，包括细胞形态、铁死亡相关理化指标和基因表达的变化。本文综述从铁代谢异常、胱氨酸/谷胱甘肽/谷胱甘肽过氧化物酶4（Cystine/GSH/GPX4）轴失衡和脂质过氧化这三个关键方面聚焦铁死亡与男性生殖系统疾病的关联。
