Bai Jing-Xing, Huang Yin, Cao De-Hong, Liu Liang-Ren
Department of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China .
Zhonghua Nan Ke Xue. 2024 Mar;30(3):272-276.
Prostate cancer (PCa) is currently the second most common malignancy in men worldwide，and its incidence rate is on the rise. Most cases of PCa are treated by radical prostatectomy, but with the development of medical imaging and innovation in therapeutic theories and technology, focal therapy has shown better application prospects in the treatment of PCa. Compared with radical prostatectomy, focal therapy yields satisfactory results in terms of effectiveness and reduction of complications in addition to avoidance of overtreatment and treatment-related financial burden. This article reviews the strategies of focal therapy for PCa, including cryoablation, high-intensity focused ultrasound, irreversible electroporation, and photodynamic therapy, with an analysis of the clinical trials in recent years.
前列腺癌（PCa）是目前全球男性中第二常见的恶性肿瘤，其发病率呈上升趋势。大多数前列腺癌病例通过根治性前列腺切除术进行治疗，但随着医学影像学的发展以及治疗理论和技术的创新，聚焦治疗在前列腺癌治疗中显示出更好的应用前景。与根治性前列腺切除术相比，聚焦治疗除了可避免过度治疗和治疗相关的经济负担外，在有效性和减少并发症方面也能产生令人满意的结果。本文综述了前列腺癌聚焦治疗的策略，包括冷冻消融、高强度聚焦超声、不可逆电穿孔和光动力疗法，并分析了近年来的临床试验。
