Department of Oral and Maxillofacial Surgery and Hospital Dentistry, Naval Medical Center San Diego, San Diego, CA, USA.
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
NeuroRehabilitation. 2024;55(3):319-327. doi: 10.3233/NRE-230253.
Mandibular reconstruction has historically been challenging due to the complex, highly functional, and esthetic nature of the anatomy. The most common etiologies of these defects requiring resection include trauma, benign tumors, and malignant pathology. Mandibular defects have been treated with little consideration for neural reconstruction, leaving patient's orally incompetent with associated social stigma. Although recent advances in reconstructive techniques improve oral rehabilitation, immediate inferior alveolar nerve (IAN) reconstruction has not been widely adapted.
Here-in we seek to discuss the innovations of neural reconstruction of large segment mandibular defects and associated IAN defects and present an example case performed at Naval Medical Center San Diego (NMCSD).
Pertinent literature discussing maxillofacial reconstruction and nerve repair using autogenous nerve harvest and allograft was queried from available online resources.
Six patients have received immediate reconstruction of the IAN using processed nerve allograft over the past three years. All obtained sensation to S3 within six months of surgery.
IAN repair using nerve allografts in conjunction with free flap reconstruction for large mandibular defects is a viable treatment and should be the new paradigm in maxillofacial reconstruction as it provides substantial quantifiable and qualitative improvements in social, functional, and esthetic outcomes of care.
由于下颌骨解剖结构的复杂性、高度功能性和美学特性,下颌骨重建一直具有挑战性。需要切除的这些缺陷最常见的病因包括创伤、良性肿瘤和恶性病变。下颌骨缺损的治疗很少考虑到神经重建,导致患者无法正常进行口腔活动,并伴有相关的社会耻辱感。尽管最近在重建技术方面取得了进展,改善了口腔康复,但即时下颌神经 (IAN) 重建尚未得到广泛应用。
本文旨在讨论大型节段性下颌骨缺损及相关 IAN 缺损的神经重建创新,并介绍在圣地亚哥海军医疗中心 (NMCSD) 进行的一个病例。
从现有在线资源中查询了讨论使用自体神经采集和同种异体神经修复颌面重建和神经修复的相关文献。
在过去三年中,有 6 名患者接受了使用处理过的同种异体神经进行 IAN 的即时重建。所有患者在手术后 6 个月内均获得 S3 感觉。
使用同种异体神经移植结合游离皮瓣重建治疗大型下颌骨缺损的 IAN 修复是一种可行的治疗方法,应成为颌面重建的新范例,因为它在社会、功能和美学结果方面提供了显著的量化和定性改善。