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Adding hetrombopag to cyclosporine a improved response of patients with newly diagnosed transfusion-dependent non-severe aplastic anemia.

作者信息

Shen Shupei, Hu Qinglin, Yang Chen, Jiang Zeyu, Chen Miao, Han Bing

机构信息

Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing, 100730, China.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academe of Medical Science, Beijing, 100730, China.

出版信息

Ann Hematol. 2024 Oct;103(10):4247-4249. doi: 10.1007/s00277-024-05941-3. Epub 2024 Aug 23.

DOI:10.1007/s00277-024-05941-3
PMID:39177798
Abstract
摘要

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1
Adding hetrombopag to cyclosporine a improved response of patients with newly diagnosed transfusion-dependent non-severe aplastic anemia.在环孢素A基础上加用海曲泊帕可改善新诊断的输血依赖型非重型再生障碍性贫血患者的反应。
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Hetrombopag plus porcine ATG and cyclosporine for the treatment of aplastic anaemia: early outcomes of a prospective pilot study.海曲泊帕联合猪抗胸腺细胞球蛋白和环孢素治疗再生障碍性贫血：一项前瞻性试点研究的早期结果
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A multicenter phase II study on the efficacy and safety of hetrombopag in patients with severe aplastic anemia refractory to immunosuppressive therapy.一项关于海曲泊帕对免疫抑制治疗难治的重型再生障碍性贫血患者疗效和安全性的多中心II期研究。
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[Prognostic factors of cyclosporine A combined with androgen in the treatment of transfusion dependent non-severe aplastic anemia].环孢素A联合雄激素治疗非重型输血依赖型再生障碍性贫血的预后因素
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Cyclosporine Therapy in Patients with Transfusion-independent Non-severe Aplastic Anemia: A Retrospective Analysis.环孢素治疗非输血依赖型非重型再生障碍性贫血患者：一项回顾性分析
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A phase I, single-sequence, open-label study to evaluate the drug-drug interaction between hetrombopag and cyclosporine in healthy Chinese subjects.一项评价健康中国受试者中替莫唑胺与环孢菌素药物相互作用的 I 期、单序列、开放性研究。
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本文引用的文献

1
A multicenter phase II study on the efficacy and safety of hetrombopag in patients with severe aplastic anemia refractory to immunosuppressive therapy.一项关于海曲泊帕对免疫抑制治疗难治的重型再生障碍性贫血患者疗效和安全性的多中心II期研究。
Ther Adv Hematol. 2022 Mar 30;13:20406207221085197. doi: 10.1177/20406207221085197. eCollection 2022.
2
Hetrombopag: First Approval.替莫泊珠单抗：首次批准。
Drugs. 2021 Sep;81(13):1581-1585. doi: 10.1007/s40265-021-01575-1.
3
Guidelines for the diagnosis and management of aplastic anaemia.再生障碍性贫血诊断与治疗指南。
Br J Haematol. 2009 Oct;147(1):43-70. doi: 10.1111/j.1365-2141.2009.07842.x. Epub 2009 Aug 10.
4
Natural history of transfusion-independent non-severe aplastic anemia in children.儿童非重型非输血依赖型再生障碍性贫血的自然病史。
Int J Hematol. 2009 May;89(4):409-413. doi: 10.1007/s12185-009-0302-9. Epub 2009 Apr 3.