Cundy T, Hand D J, Oliver D O, Woods C G, Wright F W, Kanis J A
Br Med J (Clin Res Ed). 1985 Jan 26;290(6464):271-5. doi: 10.1136/bmj.290.6464.271.
To identify patients at risk from renal bone disease we compared the demographic characteristics of 243 patients with end stage renal failure grouped according to the presence (97 (40%] or absence of severe renal bone disease as judged by histological criteria. Youth, female sex, tubulointerstitial types of nephropathy, and a long duration of uraemia were all identified as significant independent risk factors for the development of bone disease. The relative risks from being female and having tubulointerstitial renal disease were separately identifiable when the estimated observation of renal failure was short (less than four years). The identification of patients at high risk from bone disease may clarify the pathogenesis and treatment strategies of renal osteodystrophy.
为了识别有患肾性骨病风险的患者，我们比较了243例终末期肾衰竭患者的人口统计学特征，这些患者根据组织学标准判断是否存在（97例[40%]）严重肾性骨病进行分组。年轻、女性、肾小管间质类型的肾病以及长期尿毒症均被确定为骨病发生的显著独立危险因素。当肾衰竭的估计观察期较短（少于四年）时，女性和患有肾小管间质肾病的相对风险可分别识别。识别有高骨病风险的患者可能会阐明肾性骨营养不良的发病机制和治疗策略。
