National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, PR China.
Postdoctoral Research Station of China Academy of Chinese Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, PR China.
J Diabetes Complications. 2024 Oct;38(10):108848. doi: 10.1016/j.jdiacomp.2024.108848. Epub 2024 Aug 20.
Diabetes is a major risk factor for cardiovascular diseases, and myocardial damage caused by hyperglycemia is the main cause of heart failure. However, there is still a lack of systematic understanding of myocardial damage caused by diabetes. At present, we believe that the cellular inflammatory damage caused by hyperglycemia is one of the causes of diabetic cardiomyopathy. Pyroptosis, as a proinflammatory form of cell death, is closely related to the occurrence and development of diabetic cardiomyopathy. Therefore, this paper focuses on the important role of inflammation in the occurrence and development of diabetic cardiomyopathy. From the perspective of pyroptosis, we summarize the pyroptosis of different types of cells in diabetic cardiomyopathy and its related signaling pathways. It also summarizes the treatment of diabetic cardiomyopathy, hoping to provide methods for the prevention and treatment of diabetic cardiomyopathy by inhibiting pyroptosis.
糖尿病是心血管疾病的主要危险因素，高血糖引起的心肌损伤是心力衰竭的主要原因。然而，人们对糖尿病引起的心肌损伤仍缺乏系统认识。目前，我们认为高血糖引起的细胞炎症损伤是糖尿病心肌病的原因之一。细胞焦亡作为一种促炎形式的细胞死亡，与糖尿病心肌病的发生发展密切相关。因此，本文重点关注炎症在糖尿病心肌病发生发展中的重要作用。从细胞焦亡的角度，我们总结了糖尿病心肌病中不同类型细胞的焦亡及其相关信号通路。还总结了糖尿病心肌病的治疗方法，希望通过抑制细胞焦亡为糖尿病心肌病的防治提供方法。
