Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell. 2024 Aug 22;187(17):4549-4551. doi: 10.1016/j.cell.2024.07.032.
Respiratory virus infections may cause profound respiratory illness, yet the factors that underlie disease severity are not well understood. In this issue of Cell, Jia, Crawford, et al. identify the role of oleoyl-ACP-hydrolase (OLAH) in mediating life-threatening inflammation associated with viral respiratory disease severity.
呼吸道病毒感染可能导致严重的呼吸道疾病，但目前尚不清楚导致疾病严重程度的因素。在本期《Cell》杂志中，Jia、Crawford 等人研究发现，油酰基-ACP 水解酶（OLAH）在介导与病毒引起的呼吸道疾病严重程度相关的致命性炎症中发挥作用。
