Wang Shengwen, Lin Xiaofei, Zhou Yu, Yang Xin, Ou Mingming, Zhang Linxin, Wang Yumei, Gao Jing
Huai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Department of Children's Rehabilitation, Jiangsu Province, China.
Huai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Department of Pediatrics, Jiangsu Province, China.
J Pediatr (Rio J). 2025 Jan-Feb;101(1):74-81. doi: 10.1016/j.jped.2024.07.009. Epub 2024 Aug 21.
This study aimed to investigate changes in the blood metabolic profiles of newborns with varying intrauterine growth conditions. Specifically, we analyzed the levels of amino acids, carnitine, and succinylacetone among full-term newborns, including small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). We aim to identify differential metabolites and metabolic pathways that may offer insights into clinical interventions.
A total of 5106 full-term newborns were included in the study. Blood samples were obtained from all newborns between 3 and 5 days after birth and analyzed using tandem mass spectrometry to detect blood metabolites. Subsequently, we screened for different metabolites and metabolic pathways among the groups using the MetaboAnalystR package (Version 1.0.1) in R software (R-3.6.0).
The levels of blood amino acids and carnitine metabolism differed significantly among newborns with varying intrauterine growth conditions. Full-term SGA newborns exhibited a decrease in multiple amino acids and an increase in multiple carnitines, while full-term LGA newborns showed an increase in multiple amino acids and acylcarnitines.
Continuous monitoring of the short-term and long-term growth and metabolic status of full-term SGA and LGA newborns is warranted with individualized dietary and nutritional adjustments to promote healthy growth in a timely manner. The findings of this research contribute to the broader understanding of SGA/LGA and shall inform future research on metabolomics, interventions, and long-term outcomes.
本研究旨在调查不同宫内生长状况的新生儿血液代谢谱的变化。具体而言，我们分析了足月新生儿（包括小于胎龄儿（SGA）、适于胎龄儿（AGA）和大于胎龄儿（LGA））的氨基酸、肉碱和琥珀酰丙酮水平。我们旨在识别可能为临床干预提供见解的差异代谢物和代谢途径。
本研究共纳入5106例足月新生儿。在出生后3至5天从所有新生儿采集血样，并使用串联质谱法分析以检测血液代谢物。随后，我们使用R软件（R-3.6.0）中的MetaboAnalystR软件包（版本1.0.1）在各组中筛选不同的代谢物和代谢途径。
不同宫内生长状况的新生儿血液氨基酸和肉碱代谢水平存在显著差异。足月SGA新生儿多种氨基酸水平降低，多种肉碱水平升高，而足月LGA新生儿多种氨基酸和酰基肉碱水平升高。
有必要对足月SGA和LGA新生儿的短期和长期生长及代谢状况进行持续监测，并进行个体化饮食和营养调整，以促进其及时健康成长。本研究结果有助于更广泛地了解SGA/LGA，并为未来关于代谢组学、干预措施和长期结局的研究提供参考。
