Suppr超能文献

德国癌症和其他慢性病患者当前自杀意念和终生自杀企图的流行率:来自代表性社区队列的不同关联证据。

Prevalence of current suicidal thoughts and lifetime suicide attempts in individuals with cancer and other chronic diseases in Germany: Evidence for differential associations from a representative community cohort.

机构信息

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Institute for Medical Biometry, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

出版信息

J Affect Disord. 2024 Dec 15;367:193-201. doi: 10.1016/j.jad.2024.08.093. Epub 2024 Aug 22.

Abstract

BACKGROUND

Research indicates an elevated risk for suicidal thoughts and behaviors (STBs) among individuals with cancer, but community-based studies on the prevalence of STBs in comparison to the general population and other chronic diseases are lacking.

METHODS

Data was drawn from the representative population-based, prospective Gutenberg Health Study (GHS). Participants (N = 12,382; age: M = 59.5, SD = 10.8; 48.9 % women) completed highly standardized medical assessments and validated questionnaires such as the PHQ-9. In addition to prevalence estimates (stratified by STBs and gender), logistic regression models were calculated (controlling for confounders).

RESULTS

The sample included 1910 individuals with cancer, 8.2 % of whom reported current suicidal thoughts and 2.0 % reported lifetime suicide attempts. There was neither a significant association between a cancer diagnosis and suicidal thoughts (p = .077) nor suicide attempts (p = .17) in models adjusting for age, gender, and income. Other chronic diseases were linked to suicidal thoughts and attempts only in men.

LIMITATIONS

Although the investigation of the two kinds of STB are a strength of the study, the items' different time frames complicate comparisons. In addition, the cross-sectional design limits the ability to understand observed relationships and to identify periods of risk.

CONCLUSION

This study expands the evidence base regarding the vulnerability to STBs in individuals with cancer, including long-term survivors. It highlights their heterogeneity, differential risk factors underlying suicidal thoughts and attempts, and the relevance of other (contextual) factors shaping an individual's susceptibility to suicidal crises.

摘要

背景

研究表明,癌症患者自杀念头和行为(STB)的风险增加,但缺乏与一般人群和其他慢性疾病相比,基于社区的 STB 患病率研究。

方法

数据来自具有代表性的基于人群的前瞻性哥廷根健康研究(GHS)。参与者(N=12382;年龄:M=59.5,SD=10.8;48.9%女性)完成了高度标准化的医学评估和经过验证的问卷,如 PHQ-9。除了患病率估计值(按 STB 和性别分层)外,还计算了逻辑回归模型(控制混杂因素)。

结果

该样本包括 1910 名癌症患者,其中 8.2%报告有当前自杀念头,2.0%报告有自杀未遂史。在调整年龄、性别和收入的模型中,癌症诊断与自杀念头(p=0.077)或自杀未遂(p=0.17)之间均无显著关联。其他慢性疾病仅与男性的自杀念头和自杀企图有关。

局限性

尽管调查这两种 STB 是该研究的一个优势,但项目的不同时间框架使比较复杂化。此外,横断面设计限制了理解观察到的关系和确定风险期的能力。

结论

本研究扩展了关于癌症患者易患 STB 的证据基础,包括长期幸存者。它突出了他们的异质性、自杀念头和自杀企图背后的不同风险因素,以及其他(背景)因素对个体易患自杀危机的影响。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验