Section of Cardiology, John W. Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, United States of America.
Advanced Heart Failure Therapies Program, University of Louisville Health-Jewish Hospital, 201 Abraham Flexner Way, Suite 1001, Louisville, KY 40202, United States of America.
Int J Cardiol. 2024 Nov 15;415:132478. doi: 10.1016/j.ijcard.2024.132478. Epub 2024 Aug 22.
Postmenopausal women are overrepresented in the preserved ejection heart failure population. Expansion of visceral and epicardial adipose tissue during the menopause transition leads to local and low-grade systemic inflammation that in turn contributes to left ventricular concentric remodeling, diastolic dysfunction and the development and progression of preserved ejection fraction. In contrast to visceral adipose tissue imaging, epicardial adipose tissue can be inexpensively imaged on low radiation coronary calcium score computerized tomography examination. The menopause transition provides a unique time frame to evaluate the contribution of epicardial adipose tissue expansion to the pathogenesis of preserved ejection heart failure.
绝经后女性在射血分数保留心力衰竭人群中占比较高。绝经过渡期间内脏和心外膜脂肪组织的扩张会导致局部和低度全身炎症，进而导致左心室向心性重构、舒张功能障碍以及射血分数保留心力衰竭的发生和进展。与内脏脂肪组织成像不同，心外膜脂肪组织可以在低辐射冠状动脉钙评分计算机断层扫描检查中进行廉价成像。绝经过渡提供了一个独特的时间框架来评估心外膜脂肪组织扩张对射血分数保留心力衰竭发病机制的贡献。
