Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS South Tower, Suite 700, Toronto, Ontario M5G 1L7, Canada; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS South Tower, Suite 700, Toronto, Ontario M5G 1L7, Canada.
Drug Discov Today. 2024 Oct;29(10):104144. doi: 10.1016/j.drudis.2024.104144. Epub 2024 Aug 22.
Chemical probes and chemogenomic compounds are valuable tools to link gene to phenotype, explore human biology, and uncover novel targets for precision medicine. The mission of the Target 2035 initiative is to discover chemical tools for all human proteins by the year 2035. Here, we draw a landscape of the current chemical coverage of human biological pathways. Although available chemical tools target only 3% of the human proteome, they already cover 53% of human biological pathways and represent a versatile toolkit to dissect a vast portion of human biology. Pathways targeted by existing drugs may be enriched in unknown but valid drug targets and could be prioritized in future Target 2035 efforts.
化学探针和化学基因组化合物是将基因与表型联系起来、探索人类生物学和发现精准医学新靶点的有价值的工具。2035 年目标倡议的使命是到 2035 年为所有人类蛋白质发现化学工具。在这里，我们描绘了当前人类生物途径化学覆盖范围的全景。尽管现有的化学工具仅靶向人类蛋白质组的 3%，但它们已经覆盖了 53%的人类生物途径，代表了一个多功能工具包，可以剖析人类生物学的很大一部分。现有药物靶向的途径可能富含未知但有效的药物靶点，可以在未来的 2035 年目标努力中优先考虑。
