Internal Medicine, University of California Irvine Medical Center, Orange, California, USA
Hematology/Oncology, University of California Irvine Medical Center, Orange, California, USA.
BMJ Case Rep. 2024 Aug 22;17(8):e256449. doi: 10.1136/bcr-2023-256449.
A woman in her 40s with no medical history presented on hospital day #0 with 3 days of epigastric pain, nausea, vomiting and bloody diarrhoea. Initial blood work demonstrated acute kidney injury with metabolic acidosis with an elevated anion gap, thrombocytopenia, an elevated lactate dehydrogenase, and an undetectable haptoglobin. She was quickly diagnosed with haemolytic uraemic syndrome from Shiga toxin-producing O157:H7 Her microangiopathic haemolytic anaemia and renal failure progressively worsened and only improved after the initiation of eculizumab, a monoclonal antibody directed against complement component C5. We report a case of Shiga toxin-producing -haemolytic uraemia syndrome with a complement-mediated component.
一位 40 多岁的女性，无病史，于入院第 0 天出现 3 天的上腹痛、恶心、呕吐和血便。初步血液检查显示急性肾损伤合并代谢性酸中毒、阴离子间隙升高、血小板减少、乳酸脱氢酶升高和触珠蛋白检测不到。她很快被诊断为产志贺毒素 O157：H7 的溶血性尿毒综合征。她的微血管病性溶血性贫血和肾衰竭逐渐恶化，只有在开始使用针对补体成分 C5 的单克隆抗体依库珠单抗后才有所改善。我们报告了一例产志贺毒素溶血性尿毒综合征伴补体介导成分的病例。
