Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
J Pharmacol Sci. 2024 Oct;156(2):82-85. doi: 10.1016/j.jphs.2024.07.010. Epub 2024 Jul 30.
Neohesperidin, a citrus flavonoid, shows potential for activating the mechanistic target of rapamycin complex 1 (mTORC1). Here, the antidepressant-like effect of neohesperidin was examined in male ICR mice (naïve mice and mice treated repeatedly with prednisolone, a synthetic glucocorticoid, which induces depression-like behavior). Oral neohesperidin administration exerted an antidepressant-like effect in the forced swim test 1 h post-treatment, in naïve mice; this effect was no longer observed at 24 h. Neohesperidin also reversed prednisolone-induced depression-like behavior. This effect was blocked by infusing rapamycin, an mTORC1 inhibitor, into the medial prefrontal cortex. Neohesperidin may rapidly produce an antidepressant-like effect.
新橙皮苷是一种柑橘类黄酮，具有激活雷帕霉素靶蛋白复合物 1（mTORC1）的潜力。在这里，研究了新橙皮苷在雄性 ICR 小鼠（未处理的小鼠和反复用合成糖皮质激素地塞米松处理的小鼠，地塞米松可诱导抑郁样行为）中的抗抑郁样作用。新橙皮苷在未处理的小鼠中，在处理后 1 小时的强迫游泳试验中表现出抗抑郁样作用，但在 24 小时后则不再观察到这种作用。新橙皮苷还可逆转地塞米松诱导的抑郁样行为。这种作用被注入内侧前额叶皮质的雷帕霉素（mTORC1 抑制剂）所阻断。新橙皮苷可能会迅速产生抗抑郁样作用。
