School of Kinesiology and Health Sciences, Laurentian University, Sudbury, Ontario, Canada.
The Occupational Health Clinics for Ontario Workers, Sudbury, Ontario, Canada.
Am J Ind Med. 2024 Oct;67(10):933-941. doi: 10.1002/ajim.23646. Epub 2024 Aug 23.
A retrospective cohort study was conducted to estimate associations between an ultrafine aluminum powder, McIntyre Powder (MP), and cardiovascular disease incidence in a cohort of mine workers from Ontario, Canada. Disease outcomes included ischemic heart disease (IHD), acute myocardial infarction (AMI), congestive heart failure (CHF), and strokes and transient ischemic attacks (STIA).
Using work history records from the Ontario Mining Master File (MMF) mine workers were followed for disease incidence in administrative health records. The analysis included 25,813 mine workers who were exposed to MP between 1943 and 1979 and followed for cardiovascular disease (CVD) diagnoses between 2006 and 2018. Cardiovascular disease cases were ascertained using physician, hospital, and ambulatory care records. Poisson regression models were used to estimate age and birth-year adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) for associations between MP exposure and CVD outcomes.
Ever-exposure to MP was positively associated with modest increases in the incidence rate of IHD, AMI, and CHF, but not STIA, using both assessment approaches. Duration of self-reported MP exposure was positively associated with monotonically increasing rates of IHD and AMI compared to never-exposed miners, with the greatest association observed among miners with >20 years of exposure (for IHD: RR 1.24, 95% CI: 0.91-1.68; and for AMI: RR 1.52, 95% CI 1.01-2.28).
Mine workers ever-exposed to MP had modestly elevated rates of CVD. The rate of CVD diagnoses appeared to increase with longer duration of exposure when assessed by both self-reported exposure and through historical records.
一项回顾性队列研究旨在评估安大略省加拿大矿工队列中超细铝粉 McIntyre Powder（MP）与心血管疾病发病之间的关联。疾病结局包括缺血性心脏病（IHD）、急性心肌梗死（AMI）、充血性心力衰竭（CHF）以及中风和短暂性脑缺血发作（STIA）。
利用安大略矿业主文件（MMF）中的工作史记录，根据行政健康记录对矿工进行疾病发病情况随访。分析包括 1943 年至 1979 年期间暴露于 MP 的 25813 名矿工，并在 2006 年至 2018 年期间随访心血管疾病（CVD）诊断。使用医生、医院和门诊护理记录确定心血管疾病病例。使用泊松回归模型估计 MP 暴露与 CVD 结局之间的年龄和出生年份调整发病率比（RR）和 95%置信区间（CI）。
使用两种评估方法，曾经暴露于 MP 与 IHD、AMI 和 CHF 的发病率呈适度增加相关，但与 STIA 无关。与从未暴露于 MP 的矿工相比，自我报告的 MP 暴露持续时间与 IHD 和 AMI 的发病率呈单调递增相关，暴露时间超过 20 年的矿工的关联最大（IHD：RR 1.24，95%CI：0.91-1.68；AMI：RR 1.52，95%CI：1.01-2.28）。
曾经暴露于 MP 的矿工 CVD 发病率略高。当通过自我报告的暴露和历史记录进行评估时，暴露时间似乎与 CVD 诊断率的增加有关。
