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Molecular architecture of mammalian pyruvate dehydrogenase complex.

作者信息

Chen Maofei, Song Yutong, Zhang Sensen, Zhang Yitang, Chen Xudong, Zhang Minghui, Han Meng, Gao Xin, Li Sai, Yang Maojun

机构信息

Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Ministry of Education Key Laboratory of Protein Science, Tsinghua University, Beijing 100084, China.

出版信息

Protein Cell. 2025 Jan 4;16(1):72-78. doi: 10.1093/procel/pwae044.

DOI:10.1093/procel/pwae044
PMID:39180277
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11700594/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/11700594/3de6346b9fb3/pwae044_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/11700594/a57bbb379b45/pwae044_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/11700594/3de6346b9fb3/pwae044_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/11700594/a57bbb379b45/pwae044_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e59/11700594/3de6346b9fb3/pwae044_fig2.jpg

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Molecular architecture of mammalian pyruvate dehydrogenase complex.哺乳动物丙酮酸脱氢酶复合体的分子结构
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本文引用的文献

1
The pyruvate dehydrogenase complex: Life's essential, vulnerable and druggable energy homeostat.丙酮酸脱氢酶复合物：生命必需、脆弱且可药物干预的能量动态平衡器。
Mitochondrion. 2023 May;70:59-102. doi: 10.1016/j.mito.2023.02.007. Epub 2023 Mar 1.
2
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney.牛肾中内源性2-氧代戊二酸和丙酮酸脱氢酶复合物的结构与比较
Cell Discov. 2022 Nov 22;8(1):126. doi: 10.1038/s41421-022-00487-y.
3
Integrative structure of a 10-megadalton eukaryotic pyruvate dehydrogenase complex from native cell extracts.
从天然细胞提取物中整合 1000 万道尔顿真核丙酮酸脱氢酶复合物的结构。
Cell Rep. 2021 Feb 9;34(6):108727. doi: 10.1016/j.celrep.2021.108727.
4
Pyruvate dehydrogenase deficiency: morphological and metabolic effects, creation of animal model to search for curative treatment.丙酮酸脱氢酶缺乏症：形态和代谢效应，创建动物模型以寻找治疗方法。
Folia Morphol (Warsz). 2020;79(2):191-197. doi: 10.5603/FM.a2020.0020. Epub 2020 Feb 19.
5
The pyruvate dehydrogenase complexes: structure-based function and regulation.丙酮酸脱氢酶复合物：基于结构的功能与调控
J Biol Chem. 2014 Jun 13;289(24):16615-23. doi: 10.1074/jbc.R114.563148. Epub 2014 May 5.
6
Subunit and catalytic component stoichiometries of an in vitro reconstituted human pyruvate dehydrogenase complex.体外重组人丙酮酸脱氢酶复合体的亚基和催化成分化学计量比
J Biol Chem. 2009 May 8;284(19):13086-98. doi: 10.1074/jbc.M806563200. Epub 2009 Feb 24.
7
Extended polypeptide linkers establish the spatial architecture of a pyruvate dehydrogenase multienzyme complex.延长的多肽连接体构建了丙酮酸脱氢酶多酶复合体的空间结构。
Structure. 2008 Jan;16(1):93-103. doi: 10.1016/j.str.2007.10.017.
8
How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex.二氢硫辛酰胺脱氢酶结合蛋白如何在人丙酮酸脱氢酶复合体中结合二氢硫辛酰胺脱氢酶。
J Biol Chem. 2006 Jan 6;281(1):648-55. doi: 10.1074/jbc.M507850200. Epub 2005 Nov 1.
9
The molecular origins of specificity in the assembly of a multienzyme complex.多酶复合物组装特异性的分子起源
Structure. 2005 Aug;13(8):1119-30. doi: 10.1016/j.str.2005.04.021.
10
3D electron microscopy reveals the variable deposition and protein dynamics of the peripheral pyruvate dehydrogenase component about the core.三维电子显微镜揭示了外周丙酮酸脱氢酶组分围绕核心的可变沉积和蛋白质动态变化。
Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7015-20. doi: 10.1073/pnas.0732060100. Epub 2003 May 19.