Raymond Purves Bone and Joint Research Laboratory, Kolling Institute, Northern Sydney Local Health District, St. Leonards, New South Wales, Australia.
Arthropharm Australia Pharmaceuticals Pty Ltd, Bondi Junction, Sydney, New South Wales, Australia.
J Cell Mol Med. 2024 Aug;28(16):e70033. doi: 10.1111/jcmm.70033.
The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID-19 disease impacts on endothelial cell properties that lead to much of its associated symptomatology. This places the endothelial cell as a prominent cell type to target therapeutically in the treatment of this disorder. Advances in glycosaminoglycan analytical techniques and functional glycomics have improved glycosaminoglycan mimetics development, providing agents that can more appropriately target various aspects of the behaviour of the endothelial cell in-situ and have also provided polymers with potential to prevent viral infection. Thus, promising approaches are being developed to combat COVID-19 disease and the plethora of symptoms this disease produces. Glycosaminoglycan mimetics that improve endothelial glycocalyx boundary functions have promising properties in the prevention of viral infection, improve endothelial cell function and have disease-modifying potential. Endothelial cell integrity, forming tight junctions in cerebral cell populations in the blood-brain barrier, prevents the exposure of the central nervous system to circulating toxins and harmful chemicals, which may contribute to the troublesome brain fogging phenomena reported in cognitive processing in long COVID disease.
本研究旨在回顾内皮细胞在正常组织功能中的作用，并展示 COVID-19 疾病如何影响内皮细胞特性，从而导致其相关症状的发生。这使得内皮细胞成为治疗这种疾病的一个重要的治疗靶点。糖胺聚糖分析技术和功能糖组学的进步促进了糖胺聚糖模拟物的发展，提供了能够更恰当地针对内皮细胞在原位行为的各个方面的药物，并为具有预防病毒感染潜力的聚合物提供了可能性。因此，正在开发有前途的方法来对抗 COVID-19 疾病及其产生的大量症状。改善内皮糖萼边界功能的糖胺聚糖模拟物在预防病毒感染、改善内皮细胞功能和具有疾病修饰潜力方面具有良好的特性。内皮细胞完整性在血脑屏障的脑细胞群中形成紧密连接，可防止中枢神经系统暴露于循环毒素和有害化学物质中，这可能有助于解释在长 COVID 疾病的认知处理中报告的令人困扰的大脑模糊现象。
