Clinical Neurophysiology Section, Clínica Universidad de Navarra, 31008 Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, 31080 Pamplona, Spain.
Clinical Neurophysiology Section, Clínica Universidad de Navarra, 31008 Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, 31080 Pamplona, Spain; University of Navarra, CIMA, Biomedical Engineering Program, 31008 Pamplona, Spain.
Clin Neurophysiol. 2024 Oct;166:191-198. doi: 10.1016/j.clinph.2024.08.004. Epub 2024 Aug 12.
Motor symptoms of Parkinson's disease improve during REM sleep behavior disorder movement episodes. Our aim was to study cortical activity during these movement episodes, in patients with and without Parkinson's disease, in order to investigate the cortical involvement in the generation of its electromyographic activity and its potential relationship with Parkinson's disease.
We looked retrospectively in our polysomnography database for patients with REM sleep behavior disorder, analyzing fifteen patients in total, seven with idiopathic REM sleep behavior disorder and eight associated with Parkinson's disease. We selected segments of REM sleep with the presence of movements (evidenced by electromyographic activation), and studied movement-related changes in cortical activity by averaging the electroencephalographic signal (premotor potential) and by means of time/frequency transforms.
We found a premotor potential and an energy decrease of alpha-beta oscillatory activity preceding the onset of electromyographic activity, together with an increase of gamma activity for the duration of the movement. All these changes were similarly present in REM sleep behavior disorder patients with and without Parkinson's disease.
Movement-related changes in electroencephalographic activity observed in REM sleep behavior disorder are similar to those observed during voluntary movements, regardless of the presence of Parkinson's disease motor symptoms.
These results suggest a main involvement of the cortex in the generation of the movements during REM sleep.
帕金森病的运动症状在 REM 睡眠行为障碍（RBD）运动发作期间得到改善。我们的目的是研究这些运动发作期间伴有和不伴有帕金森病的患者的皮质活动，以研究其肌电图活动的皮质参与及其与帕金森病的潜在关系。
我们回顾性地在我们的多导睡眠图数据库中寻找 RBD 患者，总共分析了 15 名患者，其中 7 名患有特发性 RBD，8 名与帕金森病相关。我们选择存在运动（通过肌电图激活证实）的 REM 睡眠片段，并通过平均脑电图信号（运动前电位）和时频变换来研究运动相关的皮质活动变化。
我们发现，在肌电图活动开始之前，存在运动前电位和 alpha-beta 振荡活动能量下降，同时伴随着运动持续期间 gamma 活动增加。这些变化在伴有和不伴有帕金森病运动症状的 RBD 患者中均相似。
在 REM 睡眠中观察到的与运动相关的脑电图活动变化与在自愿运动中观察到的变化相似，无论是否存在帕金森病运动症状。
这些结果表明，皮质在 REM 睡眠期间运动的产生中起着主要作用。
