中国戊型肝炎感染的患病率和发病率。

Prevalence and Incidence of Hepatitis E Infection in China.

作者信息

Man Sailimai, Fu Jingzhu, Yang Xiaochen, Ma Yuan, Bao Heling, Du Jing, Yu Canqing, Lv Jun, Liu Hui, Li Gang, Li Liming, Wang Bo

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Department of Evidence-based Medicine and Biostatistics, Meinian Institute of Health, Beijing, China; Meinian Public Health Institute, Peking University Health Science Center, Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.

出版信息

Clin Gastroenterol Hepatol. 2024 Aug 22. doi: 10.1016/j.cgh.2024.07.026.

DOI:10.1016/j.cgh.2024.07.026

PMID:39181429

Abstract

BACKGROUND AND AIMS

China is an endemic area for hepatitis E virus (HEV) infection. Estimating the prevalence and incidence of HEV infection in China plays a pivotal role in informing public health policies to prevent and control hepatitis E. This study aimed to investigate the prevalence of anti-HEV IgG and incidence of HEV seroconversion in China.

METHODS

This study was based on the Meinian health check-up database in China. Participants who underwent testing for anti-HEV IgG at check-up centers in 24 provinces between 2017 and 2022 were included. In the cross-sectional analyses, overall prevalence and stratified prevalence in subpopulations with various characteristics were estimated and standardized according to the 2020 census of the Chinese population. In the longitudinal analyses, the occurrence of anti-HEV IgG positivity during the follow-up was defined as an incident HEV seroconversion. Overall and stratified incidence rates were estimated and expressed as per 100 person-years. Poisson regression was used to explore risk factors associated with HEV seroconversion.

RESULTS

A total of 85,238 and 11,154 participants were included in the cross-sectional and longitudinal analyses, respectively. The prevalence of anti-HEV IgG in the general population was 18.02%. During a median follow-up of 1.2 years, the incidence rate of HEV seroconversion was 1.79 per 100 person-years. Age ≥60 years, low socioeconomic status, living in coastal areas, living in areas with high drainage density, and living in areas with high anti-HEV IgG prevalence were independent risk factors for HEV seroconversion.

CONCLUSIONS

Our findings would help inform policymaking for hepatitis E prevention and control in China as well as in other endemic regions of the world.

摘要

背景与目的

中国是戊型肝炎病毒（HEV）感染的流行地区。估计中国戊型肝炎病毒感染的患病率和发病率对于制定预防和控制戊型肝炎的公共卫生政策起着关键作用。本研究旨在调查中国抗HEV IgG的患病率和HEV血清学转换的发病率。

方法

本研究基于中国美年大健康体检数据库。纳入了2017年至2022年期间在24个省份的体检中心接受抗HEV IgG检测的参与者。在横断面分析中，根据2020年中国人口普查数据，估计并标准化了具有各种特征的亚人群中的总体患病率和分层患病率。在纵向分析中，将随访期间抗HEV IgG阳性的发生定义为新发HEV血清学转换。估计总体和分层发病率，并以每100人年表示。采用泊松回归分析探索与HEV血清学转换相关的危险因素。

结果

横断面分析和纵向分析分别纳入了85238名和11154名参与者。普通人群中抗HEV IgG的患病率为18.02%。在中位随访1.2年期间，HEV血清学转换的发病率为每100人年1.79例。年龄≥60岁、社会经济地位低、居住在沿海地区、居住在排水密度高的地区以及居住在抗HEV IgG患病率高的地区是HEV血清学转换的独立危险因素。