Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Transplant Proc. 2024 Sep;56(7):1593-1597. doi: 10.1016/j.transproceed.2024.08.009. Epub 2024 Aug 23.
We prospectively evaluated 3 cases regarding the usefulness of fully-covered self-expandable metal stents (FCSEMSs) for hepaticojejunostomy anastomotic stricture (HAS) after living donor liver transplantation (LDLT), which could not be resolved with conventional treatment using a plastic stent.
All patients underwent LDLT with Roux-en-Y reconstruction; therefore, a short-type double-balloon enteroscope was used for the endoscopic procedures. HAS was observed on enteroscopic view of endoscopy in patients 1 and 2, and cholangiography revealed dilatation of the intrahepatic bile duct. The FCSEMS was successfully placed without the report of adverse events. The FCSEMS was removed after 16 weeks, and the HAS improved in both patients. In addition, stone clearance was also achieved in patient 2. On the other hand, FCSEMS was not placed in patient 3 because there was no indication of FCSEMS placement due to the multiple segmental biliary strictures (pruned-tree appearance on cholangiography). Subsequent deceased-donor liver transplantation confirmed recurrent primary sclerosing cholangitis. In this case, magnetic resonance cholangiopancreatography (MRCP) was not performed prior to cholangiography to rule out PSC recurrence.
FCSEMS placement may be effective and safe for HAS after LDLT, which is not resolved with conventional treatment using a plastic stent. MRCP should be used to identify HAS prior to invasive cholangiography.
我们前瞻性评估了 3 例因活体肝移植 (LDLT) 后肝肠吻合口狭窄 (HAS) 而无法通过常规塑料支架治疗的完全覆膜自膨式金属支架 (FCSEMS) 的有效性,这些患者均存在 HAS。
所有患者均接受 LDLT 联合 Roux-en-Y 重建;因此,采用短型双气囊内镜进行内镜操作。患者 1 和 2 的内镜检查发现 HAS,胆管造影显示肝内胆管扩张。无不良事件报告的情况下成功放置 FCSEMS。16 周后取出 FCSEMS,2 例患者的 HAS 均得到改善。此外,患者 2 还实现了结石清除。另一方面,患者 3 未放置 FCSEMS,因为胆管造影显示多发节段性胆管狭窄(修剪树外观),无放置 FCSEMS 的指征。随后进行的尸体供肝移植证实为复发性原发性硬化性胆管炎。在这种情况下,在胆管造影前未进行磁共振胰胆管成像 (MRCP) 以排除 PSC 复发。
对于常规塑料支架治疗无效的 LDLT 后 HAS,FCSEMS 放置可能是有效且安全的。在进行有创性胆管造影前,应使用 MRCP 来识别 HAS。