胞嘧啶甲基化标记线粒体 RNA 进行降解。

Cytosine methylation flags mitochondrial RNA for degradation.

机构信息

Department of Immunobiology, University of Lausanne, 1066 Epalinges, Switzerland.

出版信息

Trends Biochem Sci. 2024 Oct;49(10):843-845. doi: 10.1016/j.tibs.2024.08.001. Epub 2024 Aug 24.

DOI:10.1016/j.tibs.2024.08.001

Abstract

Mitochondrial double-stranded RNA (dsRNA) can form spontaneously in mitochondria, blocking mitochondrial gene expression and triggering an immune response. A recent study by Kim, Tan, et al. identified a safeguard mechanism in which NOP2/Sun RNA methyltransferase 4 (NSUN4)-mediated RNA methylation (mC) recruits the RNA degradation machinery to prevent dsRNA formation.

摘要

线粒体双链 RNA（dsRNA）可在线粒体中自发形成，从而阻断线粒体基因表达并引发免疫反应。Kim、Tan 等人最近的一项研究确定了一种保护机制，即 NOP2/Sun RNA 甲基转移酶 4（NSUN4）介导的 RNA 甲基化（mC）招募 RNA 降解机制以防止 dsRNA 形成。