Sayed Osama, Abdalla Mohamed Mahmoud, Elsayed Ayman, El-Mahallawy Yehia, Al-Mahalawy Haytham
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.
Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
BDJ Open. 2024 Aug 24;10(1):69. doi: 10.1038/s41405-024-00220-9.
The aim of this study was to systematically review the literature to address the effect of strontium modified titanium implants on the osseointegration in the presence of osteoporotic conditions through animal models.
The databases (PubMed, Scopus, Web of Science, and EBSCO) were searched electronically, and manual searches were performed till December 2022 to identify preclinical studies on the osseointegration of strontium coated titanium implants in animals with induced osteoporotic conditions. The primary outcomes were the bone-implant contact percentage (BIC%), bone area (BA) from the histomorphometric analysis, and the osseointegration parameters from biomechanical tests; the secondary outcomes were the osseointegration parameters from the micro computed tomography.
Nineteen articles were included for the quantitative analysis on basis of the inclusion criteria. The results revealed that Sr-modified implants showed a significant 19.05% increase in BIC, and 15.01% increase in BA. The results of biomechanical tests indicated a significant effect in favor of Sr-coated implants. Furthermore, Results of the secondary outcomes supported the significant advantages of Sr-coated implants over the un-coated implants. The overall, systematic analysis of implants osteointegration parameters proved a significant increase in favor of Sr-coated titanium implants (P < 0.01).
The present results provide evidence that strontium-coated titanium implants enhanced the osseointegration in animal models under osteoporotic condition as this surface modification techniques have improved the mechanical and biological properties of the titanium implants.
本研究旨在通过动物模型，系统回顾文献以探讨锶改性钛植入物在骨质疏松条件下对骨整合的影响。
通过电子检索数据库（PubMed、Scopus、Web of Science和EBSCO），并进行手动检索直至2022年12月，以确定关于锶涂层钛植入物在诱导骨质疏松的动物中骨整合的临床前研究。主要结局指标为组织形态计量学分析中的骨-植入物接触百分比（BIC%）、骨面积（BA）以及生物力学测试中的骨整合参数；次要结局指标为微型计算机断层扫描的骨整合参数。
根据纳入标准，纳入19篇文章进行定量分析。结果显示，锶改性植入物的BIC显著增加19.05%，BA显著增加15.01%。生物力学测试结果表明，锶涂层植入物具有显著优势。此外，次要结局指标的结果支持锶涂层植入物相对于未涂层植入物具有显著优势。对植入物骨整合参数的总体系统分析证明，锶涂层钛植入物有显著增加（P < 0.01）。
目前的结果提供了证据，表明锶涂层钛植入物在骨质疏松条件下的动物模型中增强了骨整合，因为这种表面改性技术改善了钛植入物的机械和生物学性能。
