Shu Weitong, Huang Qianying, Chen Rui, Lan Huatao, Yu Luxin, Cui Kai, He Wanjun, Zhu Songshan, Chen Mei, Li Li, Jiang Dan, Xu Guangxian
Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The First Dongguan Affiliated Hospital, School of Medical Technology, Guangdong Medical University, Dongguan, China.
Dongguan Key Laboratory of Molecular Immunology and Cell Therapy, Dongguan, China.
Cancer Cell Int. 2024 Aug 24;24(1):298. doi: 10.1186/s12935-024-03480-5.
Gastrointestinal cancer is the most common malignancy in humans, often accompanied by poor prognosis. N6-methyladenosine (m6A) modification is widely present in eukaryotic cells as the most abundant RNA modification. It plays a crucial role in RNA splicing and processing, nuclear export, translation, and stability. Human AlkB homolog 5 (ALKBH5) is a type of RNA demethylase exhibiting abnormal expression in various gastrointestinal cancers.It is closely related to the tumorigenesis, proliferation, migration, and other biological functions of gastrointestinal cancer. However, recent studies indicated that the role and mechanism of ALKBH5 in gastrointestinal cancer are complicated and even controversial. Thus, this review summarizes recent advances in elucidating the role of ALKBH5 as a tumor suppressor or promoter in gastrointestinal cancer. It examines the biological functions of ALKBH5 and its potential as a therapeutic target, providing new perspectives and insights for gastrointestinal cancer research.
胃肠道癌是人类最常见的恶性肿瘤，通常预后较差。N6-甲基腺苷（m6A）修饰作为最丰富的RNA修饰广泛存在于真核细胞中。它在RNA剪接与加工、核输出、翻译及稳定性方面发挥着关键作用。人类烷基化修复蛋白5（ALKBH5）是一种RNA去甲基化酶，在多种胃肠道癌中表达异常。它与胃肠道癌的肿瘤发生、增殖、迁移及其他生物学功能密切相关。然而，最近的研究表明，ALKBH5在胃肠道癌中的作用和机制复杂，甚至存在争议。因此，本综述总结了在阐明ALKBH5作为胃肠道癌肿瘤抑制因子或促进因子作用方面的最新进展。它研究了ALKBH5的生物学功能及其作为治疗靶点的潜力，为胃肠道癌研究提供了新的视角和见解。
