Berger G, Hawke M, Johnson A, Proops D
Laryngoscope. 1985 Feb;95(2):193-9. doi: 10.1288/00005537-198502000-00014.
The histopathologic findings in 8 temporal bones from 5 patients with osteogenesis imperfecta congenita are reported. The otic capsule, bony walls of middle ear, and ossicles showed evidence of both deficient and abnormal ossification. Microfractures were found in the otic capsule and in the anterior process and handle of the malleus, in addition to their common location at the crura of the stapes. The cochlear and vestibular end-organs appeared normal. Pathologic changes compatible with otosclerosis were not seen. The possible implication of these changes on hearing and balance is discussed.
报告了5例先天性成骨不全患者8块颞骨的组织病理学发现。听骨囊、中耳骨壁和听小骨均显示出骨化不足和异常骨化的证据。除了在镫骨脚的常见位置外，在听骨囊以及锤骨的前突和柄部也发现了微骨折。耳蜗和前庭终器看起来正常。未发现与耳硬化症相符的病理变化。讨论了这些变化对听力和平衡的可能影响。
