Laboratory of Research in Physiology and pathophysiology, Faculty of Medicine, Saint Joseph University of Beirut, POBox. 17-5208 - Mar Mikhaël, Beirut 1104 2020, Lebanon; Laboratoire Microbiologie Santé et Environnement (LMSE), Doctoral School of Science & Technology, Faculty of Public Health, Lebanese University, Tripoli, Lebanon.
Department of Biology, Faculty of Arts and Sciences, University of Balamand, P.O. Box 100, Tripoli, Lebanon.
Brain Res Bull. 2024 Oct 1;216:111056. doi: 10.1016/j.brainresbull.2024.111056. Epub 2024 Aug 23.
The intricate interplay existing between gut microbiota and homeostasis extends to the realm of the brain, where emerging research underscores the significant impact of the microbiota on mood regulation and overall neurological well-being and vice-versa, with inflammation playing a pivotal role in mediating these complex interactions. This comprehensive review explores the complex interplay between inflammation, alterations in gut microbiota, and their impact on major depressive disorder (MDD). It provides a cohesive framework for the puzzle pieces of this triad, emphasizing recent advancements in understanding the gut microbiota and inflammatory states' contribution to the depressive features. Two directions of communication between the gut and the brain in depression are discussed, with inflammation serving as a potential modulator. Therapeutic implications were discussed as well, drawing insights from interventional studies on the effects of probiotics on gut bacterial composition and depressive symptoms. Ultimately, this review will attempt to provide a complete and valuable framework for future research and therapeutic interventions in MDD.
肠道微生物群和体内平衡之间存在的复杂相互作用延伸到大脑领域，新兴研究强调了微生物群对情绪调节和整体神经健康的重大影响，反之亦然，炎症在介导这些复杂相互作用中起着关键作用。本综述探讨了炎症、肠道微生物群改变及其对重度抑郁症（MDD）的影响之间的复杂相互作用。它为这个三联体的拼图提供了一个连贯的框架，强调了理解肠道微生物群和炎症状态对抑郁特征贡献的最新进展。讨论了抑郁症中肠道和大脑之间的两个沟通方向，炎症作为潜在的调节剂。还讨论了治疗意义，从益生菌对肠道细菌组成和抑郁症状影响的干预研究中汲取了见解。最终，本综述将尝试为 MDD 的未来研究和治疗干预提供一个完整而有价值的框架。
