Lu Yantong, Pan Guangjuan, Wei Zhiying, Li Yaohua, Pan Xiaojiao
Guangxi University of Chinese Medicine, Nanning 530200, China.
Guangxi University of Chinese Medicine, Nanning 530200, China; Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine, Nanning 530200, China.
Exp Gerontol. 2024 Oct 15;196:112559. doi: 10.1016/j.exger.2024.112559. Epub 2024 Aug 24.
Skin, as the outermost protective barrier of the body, becomes damaged with age and exposure to external stimuli. Dermal fibroblasts age and undergo apoptosis, which decreases collagen, collagen fibers, elastic fibers, hyaluronic acid, etc., leading skin to loss of elasticity and appearance of wrinkles. Skin aging is complex, involving several biological reactions，and various treatment methods are used to treat it. This review focuses on the importance of autophagy and cell proliferation in skin anti-aging, summarizes research progress on skin anti-aging by regulating autophagy and promoting the proliferation of dermal fibroblasts, and discusses future directions on skin anti-aging research.
皮肤作为人体最外层的保护屏障，会随着年龄增长和暴露于外部刺激而受损。真皮成纤维细胞会老化并发生凋亡，这会减少胶原蛋白、胶原纤维、弹性纤维、透明质酸等，导致皮肤失去弹性并出现皱纹。皮肤老化是复杂的，涉及多种生物学反应，并且使用了各种治疗方法来治疗它。本综述重点关注自噬和细胞增殖在皮肤抗衰老中的重要性，总结通过调节自噬和促进真皮成纤维细胞增殖来实现皮肤抗衰老的研究进展，并讨论皮肤抗衰老研究的未来方向。
