Morimoto K, Shimoda K, Kataura A
ORL J Otorhinolaryngol Relat Spec. 1985;47(1):26-31. doi: 10.1159/000275741.
Although prostaglandins (PGs), especially PGE2 and PGF2 alpha, are thought to be associated with inflammation, there have been no papers dealing with the synthesis of PGE2 and PGF2 alpha in human tonsillar lymphocytes. The features of PG synthesis in lymphocytes were investigated by incubating cells with radiolabelled precursors. Synthesis of PGE2 was greater than that of PGF2 alpha in tonsillar lymphocytes. PGE2 was the predominant product in the tonsillar lymphocytes of the recent infection group. There was no significant difference between T and B lymphocytes in the ratio of PGE2 and PGF2 alpha formed. A significant increase in PGE2 formed with bradykinin was found in the tonsillar hypertrophy group. The possible role of PGs in the pathogenesis and mechanism of releasing free fatty acid PG precursors from cell membranes was discussed.
尽管前列腺素（PGs），尤其是前列腺素E2（PGE2）和前列腺素F2α（PGF2α）被认为与炎症有关，但尚无关于人扁桃体淋巴细胞中PGE2和PGF2α合成的论文。通过用放射性标记的前体孵育细胞来研究淋巴细胞中PG合成的特征。扁桃体淋巴细胞中PGE2的合成大于PGF2α。PGE2是近期感染组扁桃体淋巴细胞中的主要产物。在形成的PGE2和PGF2α的比例上，T淋巴细胞和B淋巴细胞之间没有显著差异。在扁桃体肥大组中发现，缓激肽使形成的PGE2显著增加。讨论了PGs在从细胞膜释放游离脂肪酸PG前体的发病机制和机制中的可能作用。
