Biosciences Institute, São Paulo State University (UNESP), São Vicente, SP, Brazil.
Institute of Advanced Sea Studies (IEAMAR), São Paulo State University (UNESP), São Vicente, SP, Brazil.
Bull Environ Contam Toxicol. 2024 Aug 25;113(3):32. doi: 10.1007/s00128-024-03937-3.
Due to their broad-spectrum antimicrobial action and ease of synthesis, silver nanoparticles (AgNP) are one of the most widely used nanomaterials in different industrial and ecological areas. AgNP are released into marine ecosystems, nevertheless, their ecotoxicological effects have been overlooked. In this study, we evaluated the toxic effects of biogenic and synthesized AgNP (AgNP and AgNP) on sea urchin Echinometra lucunter embryos and compared them with the metal precursor silver nitrate (AgNO). Fertilized eggs were exposed to five concentrations of the test compounds and a negative control for 48 h under controlled conditions. The IC of AgNP, AgNP and AgNO were 0.31, 4.095, and 0.01 µg L, evidencing that both AgNP are less toxic than AgNO, and that AgNP is less toxic than the AgNP. Toxicity to E. lucunter embryos could be explained by the fact that Ag affects DNA replication and induces the formation of pores in the cellular wall, leading to apoptosis.
由于其广谱抗菌作用和易于合成，银纳米粒子（AgNP）是在不同工业和生态领域中应用最广泛的纳米材料之一。AgNP 被释放到海洋生态系统中，但它们的生态毒理学效应却被忽视了。在本研究中，我们评估了生物合成和合成的 AgNP（AgNP 和 AgNP）对海胆 Echinometra lucunter 胚胎的毒性作用，并将其与金属前体硝酸银（AgNO）进行了比较。在受控条件下，将受精卵暴露于五种浓度的测试化合物和阴性对照中 48 小时。AgNP、AgNP 和 AgNO 的 IC 分别为 0.31、4.095 和 0.01µg L，表明两种 AgNP 的毒性均低于 AgNO，而 AgNP 的毒性又低于 AgNP。Ag 对 E. lucunter 胚胎的毒性可以用以下事实来解释：Ag 会影响 DNA 复制并在细胞壁上形成孔，导致细胞凋亡。
