FMIPA, Universitas Negeri Yogyakarta, Yogyakarta, Indonesia.
Faculty of Mathematics and Science, Bandung Institute of Technology, Bandung, Indonesia.
Sci Rep. 2024 Aug 26;14(1):19734. doi: 10.1038/s41598-024-70799-4.
Dayak tribes indigenous to the Indonesian island of Borneo has been using Bajakah Kalalawit (Uncaria gambir Roxb.) as traditional medicine for ages. This inspired us to develop phenolic from Bajakah Kalalawit extract as antibacterial agent. The extraction was done through decoction method and the determination of phenolic concentration was done using a visible spectrophotometer and Folin-Ciocalteu reagent (mixture of phosphotungstic and phosphomolybdic acids). We investigated the possibility of developing phenolic nanoparticle for future work. Kirby-Bauer method was used to assess antibacterial activity of phenolic against Staphylococcus aureus and the results were compared to Chloramphenicol in terms of its efficacy and duration of inhibition. This study contributes to the ongoing effort to address antibiotic resistance through the development of innovative antibacterial agents derived from natural sources. The results provide valuable insights into the potential of Bajakah Kalalawit phenolic extracts as a promising avenue for combating bacterial infections in the future.
达雅克部落是印度尼西亚婆罗洲岛上的土著居民，他们自古以来就一直将卡兰加（Uncaria gambir Roxb.）用作传统药物。这启发我们从卡兰加提取物中开发出具有抗菌作用的酚类物质。通过煮浸法进行提取，并用可见分光光度计和福林-肖卡试剂（磷钨酸和磷钼酸的混合物）测定酚类浓度。我们研究了开发酚类纳米粒子的可能性，以备将来使用。采用 Kirby-Bauer 法评估酚类物质对金黄色葡萄球菌的抗菌活性，并将其抑制效果和持续时间与氯霉素进行比较。本研究为通过开发源自天然来源的创新型抗菌剂来应对抗生素耐药性问题做出了贡献。研究结果为卡兰加酚类提取物作为未来治疗细菌感染的有前途的途径提供了有价值的见解。
