Department of Thoracic Surgery, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, PR China.
Medical School of Nantong University, Nantong, PR China.
Medicine (Baltimore). 2024 Aug 23;103(34):e39398. doi: 10.1097/MD.0000000000039398.
Luteolin (3, 4, 5, 7-tetrahydroxyflavone) are natural flavonoids widely found in vegetables, fruits and herbs, with anti-tumor, anti-inflammatory and antioxidant effects, and also play an anti-cancer effect in various cancers such as lung, breast, prostate, and liver cancer, etc. Specifically, the anti-cancer mechanism includes regulation of various signaling pathways to induce apoptosis of tumor cells, inhibition of tumor cell proliferation and metastasis, anti-angiogenesis, regulation of immune function, synergistic anti-cancer drugs and regulation of reactive oxygen species levels of tumor cells. Specific anti-cancer mechanisms include regulation of various signaling pathways to induce apoptosis, inhibition of tumor cell proliferation and metastasis, anti-angiogenesis, reversal of epithelial-mesenchymal transition, regulation of immune function, synergism with anti-cancer drugs and regulation of reactive oxygen species levels in tumor cells. This paper integrates the latest cutting-edge research on luteolin and combines it with the prospect of future clinical applications, aiming to explore the mechanism of luteolin exerting different anticancer effects through the regulation of different signaling pathways, so as to provide a practical theoretical basis for the use of luteolin in clinical treatment and hopefully provide some reference for the future research direction of luteolin.
木樨草素（3,4,5,7-四羟基黄酮）是广泛存在于蔬菜、水果和草药中的天然类黄酮，具有抗肿瘤、抗炎和抗氧化作用，对肺癌、乳腺癌、前列腺癌和肝癌等多种癌症也具有抗癌作用。具体而言，其抗癌机制包括调节各种信号通路诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖和转移、抗血管生成、调节免疫功能、与抗癌药物协同作用以及调节肿瘤细胞内活性氧水平。具体的抗癌机制包括调节各种信号通路诱导凋亡、抑制肿瘤细胞增殖和转移、抗血管生成、上皮间质转化的逆转、调节免疫功能、与抗癌药物协同作用以及调节肿瘤细胞内活性氧水平。本文整合了木樨草素的最新前沿研究，并结合未来临床应用的前景，旨在探讨木樨草素通过调节不同信号通路发挥不同抗癌作用的机制，为木樨草素在临床治疗中的应用提供实用的理论基础，并有望为木樨草素的未来研究方向提供一些参考。
