Haider Syed Hamza, Irfan Areeka, Sheikh Samir Mustafa, Abid Muhammad Taha, Naz Turba, Abbas Mudassir, Raza Alishba
MBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, Pakistan.
Future Sci OA. 2024 Dec 31;10(1):2365125. doi: 10.1080/20565623.2024.2365125. Epub 2024 Aug 25.
This meta-analysis investigates the association between testosterone replacement therapy [TRT] and carotid artery atherosclerosis. 3 databases were searched for studies up to June 2023 per the PRISMA guidelines. The eligibility criteria comprised RCTs and observational studies involving hypogonadal males receiving exogenous testosterone, in which CIMT was assessed. CAA was the primary outcome, whereas secondary outcomes included HDL, LDL, CRP, total cholesterol and total testosterone. The statistical analysis was performed using Review Manager. Statistical analysis revealed no association between TRT and assessed outcomes. There was a significant increase in total testosterone levels, depicting indirect anti-atherosclerotic effects of TRT. Meta-analysis shows no relation between TRT and CIMT or other markers, allowing its safe usage for hypogonadal males.
本荟萃分析探讨了睾酮替代疗法（TRT）与颈动脉粥样硬化之间的关联。根据PRISMA指南，检索了3个数据库中截至2023年6月的研究。纳入标准包括涉及接受外源性睾酮的性腺功能减退男性的随机对照试验（RCT）和观察性研究，其中评估了颈动脉内膜中层厚度（CIMT）。颈动脉粥样硬化（CAA）是主要结局，而次要结局包括高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、C反应蛋白（CRP）、总胆固醇和总睾酮。使用Review Manager进行统计分析。统计分析显示TRT与评估的结局之间无关联。总睾酮水平显著升高，表明TRT具有间接抗动脉粥样硬化作用。荟萃分析表明TRT与CIMT或其他标志物之间无关联，这使得其可安全用于性腺功能减退男性。
