Scardino P T, Wheeler T M
Urology. 1985 Feb;25(2 Suppl):39-46.
To determine the prognostic significance of a routine needle biopsy of the prostate performed six to thirty-six months after the completion of definitive radiotherapy, biopsy results were analyzed in 146 patients who had no evidence of disease at the time of biopsy and who received no other therapy before proved recurrence of the tumor. Patients were followed up a mean of 3.9 years after radioactive gold seed implantation and external beam irradiation. The total dose was 8,000 rad. Among 146 patients, 56 (38%) had one or more positive biopsy results within this time interval. The positive biopsy rate correlated with the clinical stage ranging from 17 per cent in Stage B1N to 59 per cent in Stage C1. The risk of developing local recurrence or distant metastases at any given time after irradiation therapy was markedly greater in those patients with a positive biopsy result (p less than 0.0005). Prostatic biopsy is an accurate means of measuring the success of radiotherapy. A positive postirradiation biopsy result carries grave prognostic implications for the patient and indicates that the treatment has failed.
为确定在根治性放疗结束后6至36个月进行的前列腺常规穿刺活检的预后意义，对146例在活检时无疾病证据且在肿瘤复发得到证实之前未接受其他治疗的患者的活检结果进行了分析。在放射性金种子植入和外照射后，对患者进行了平均3.9年的随访。总剂量为8000拉德。在146例患者中，56例（38%）在此时间间隔内有一个或多个阳性活检结果。阳性活检率与临床分期相关，从B1N期的17%到C1期的59%不等。放疗后任何给定时间出现局部复发或远处转移的风险在活检结果为阳性的患者中明显更高（p小于0.0005）。前列腺活检是衡量放疗成功与否的准确方法。放疗后活检结果为阳性对患者具有严重的预后意义，表明治疗失败。
