Cui Xinyan, Zhou Zekun, Tu Hua, Wu Jianjun, Zhou Jian, Yi Qiao, Liu Ousheng, Dai Xiaohan
Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases, Oral Health and Academician Workstation for Oral-maxilofacial, Regenerative Medicine and Xiangya Stomatological Hospital, Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.
Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Front Physiol. 2024 Aug 9;15:1430230. doi: 10.3389/fphys.2024.1430230. eCollection 2024.
Mitophagy is a highly precise process of selective autophagy, primarily aimed at eliminating excess or damaged mitochondria to maintain the stability of both mitochondrial and cellular homeostasis. In recent years, with in-depth research into the association between mitophagy and fibrotic diseases, it has been discovered that this process may interact with crucial cellular biological processes such as oxidative stress, inflammatory responses, cellular dynamics regulation, and energy metabolism, thereby influencing the occurrence and progression of fibrotic diseases. Consequently, modulating mitophagy holds promise as a therapeutic approach for fibrosis. Currently, various methods have been identified to regulate mitophagy to prevent fibrosis, categorized into three types: natural drug therapy, biological therapy, and physical therapy. This review comprehensively summarizes the current understanding of the mechanisms of mitophagy, delves into its biological roles in fibrotic diseases, and introduces mitophagy modulators effective in fibrosis, aiming to provide new targets and theoretical basis for the investigation of fibrosis-related mechanisms and disease prevention.
线粒体自噬是一种高度精确的选择性自噬过程，主要旨在清除多余或受损的线粒体，以维持线粒体和细胞内稳态的稳定性。近年来，随着对线粒体自噬与纤维化疾病之间关联的深入研究，发现该过程可能与氧化应激、炎症反应、细胞动力学调节和能量代谢等关键细胞生物学过程相互作用，从而影响纤维化疾病的发生和发展。因此，调节线粒体自噬有望成为治疗纤维化的一种方法。目前，已确定多种调节线粒体自噬以预防纤维化的方法，分为三类：天然药物治疗、生物治疗和物理治疗。本综述全面总结了目前对线粒体自噬机制的认识，深入探讨了其在纤维化疾病中的生物学作用，并介绍了对纤维化有效的线粒体自噬调节剂，旨在为纤维化相关机制的研究和疾病预防提供新的靶点和理论依据。
