Sansgiri Tanvy Subir, Saluja Harish, Shah Seemit, Dadhich Anuj, Singh Deepak
Department of Oral and Maxillofacial Surgery, Rural Dental College, Pravara Institute of Medical Sciences, Loni, Maharashtra, India.
Ann Maxillofac Surg. 2024 Jan-Jun;14(1):52-55. doi: 10.4103/ams.ams_82_23. Epub 2024 Apr 3.
The lymph node status is a very important prognostic factor in head-and-neck cancer. The presence of metastatic lymph nodes will reduce the overall survival by 50%. Lymph node ratio (LNR) is defined as the ratio of the number of positive lymph nodes to the total number of lymph nodes dissected. The aim of the study was to investigate the prognostic value of LNR in oral squamous cell carcinoma (OSCC).
Medical records of pathologically confirmed OSCC patients who reported with loco-regional recurrence from January 2017 to January 2022 were analysed. LNR and disease-free survival (DFS) were calculated for each patient. The endpoint of the study was disease-free survival. Spearman's correlation was used to establish a correlation between DFS and LNR.
A total of 33 patients were included in the study. DFS was calculated for all the patients. LNR was calculated in patients with pathological N+ neck. There was a negative significant moderate correlation between LNR and DFS (Spearman's rho = -0.593, < 0.001). A higher LNR value of more than 0.01 was associated with a shorter DFS period. T4 tumour stage had significantly higher LNR. A positive significant moderate correlation was found between LNR and tumour stage (Spearman's rho = 0.703, = 0.01). As the T stage increased, the LNR ratio also increased. In the present study, tumour subsite tongue was associated with significantly higher LNR ( = 0.001).
LNR can be considered an independent prognostic parameter for DFS in OSCC patients with cervical lymph node metastasis.
淋巴结状态是头颈癌一个非常重要的预后因素。出现转移性淋巴结会使总生存率降低50%。淋巴结比率（LNR）定义为阳性淋巴结数量与清扫的淋巴结总数之比。本研究的目的是探讨LNR在口腔鳞状细胞癌（OSCC）中的预后价值。
分析了2017年1月至2022年1月间报告有局部区域复发的经病理确诊的OSCC患者的病历。计算每位患者的LNR和无病生存期（DFS）。研究的终点是无病生存期。采用Spearman相关性分析来确定DFS与LNR之间的相关性。
本研究共纳入33例患者。计算了所有患者的DFS。对病理N+颈部的患者计算了LNR。LNR与DFS之间存在显著的负向中度相关性（Spearman相关系数=-0.593，<0.001）。LNR值高于0.01与较短的DFS期相关。T4肿瘤分期的LNR显著更高。LNR与肿瘤分期之间存在显著的正向中度相关性（Spearman相关系数=0.703，=0.01）。随着T分期增加，LNR比率也增加。在本研究中，肿瘤亚部位舌部的LNR显著更高（=0.001）。
LNR可被视为有颈部淋巴结转移的OSCC患者DFS的一个独立预后参数。
