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一例复发性糖尿病足溃疡伴多重耐药性混合微生物感染病例

A Case of Recurrent Diabetic Foot Ulcers With Multi-drug Resistant Poly-Microbial Infections.

作者信息

Kunjalwar Radha, Pedaprolu Aditya S, Keerti Akshunna, Chaudhari Achal

机构信息

Microbiology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

General Surgery, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Jul 26;16(7):e65432. doi: 10.7759/cureus.65432. eCollection 2024 Jul.

DOI:10.7759/cureus.65432
PMID:39184718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11345028/
Abstract

For people with diabetes, diabetic foot ulcers (DFUs) are a serious condition that can result in amputations, among other dire consequences. This case report details the clinical course and management of a 40-year-old male with type II diabetes mellitus presenting with recurrent DFUs and blackening of the toes. Despite initial surgical intervention and aggressive antimicrobial therapy, the patient experienced persistent infection and graft failure, necessitating multiple treatments and ongoing care. Most of the bacteria that were identified from diabetic foot infections (DFIs) were gram-negative, and they were resistant to common treatments. The intensity of DFI was correlated with polymicrobial illnesses.

摘要

对于糖尿病患者而言，糖尿病足溃疡（DFUs）是一种严重病症，可能导致截肢以及其他严重后果。本病例报告详细介绍了一名40岁II型糖尿病男性患者的临床病程及治疗情况，该患者出现复发性糖尿病足溃疡并伴有脚趾发黑。尽管最初进行了手术干预和积极的抗菌治疗，但患者仍持续感染且移植失败，需要多次治疗和持续护理。从糖尿病足感染（DFIs）中鉴定出的大多数细菌为革兰氏阴性菌，且它们对常用治疗方法具有抗性。糖尿病足感染的严重程度与多种微生物感染相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da89/11345028/bd85ece34c46/cureus-0016-00000065432-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da89/11345028/5027c40d816b/cureus-0016-00000065432-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da89/11345028/bd85ece34c46/cureus-0016-00000065432-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da89/11345028/5027c40d816b/cureus-0016-00000065432-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da89/11345028/bd85ece34c46/cureus-0016-00000065432-i02.jpg

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本文引用的文献

1
The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes.多种微生物引起的糖尿病足感染与其严重程度及预后之间的显著关联。
Malays J Med Sci. 2019 Jan;26(1):107-114. doi: 10.21315/mjms2019.26.1.10. Epub 2019 Feb 28.
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一项大型回顾性队列研究中的糖尿病足并发症及其危险因素
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Diabetes Res Clin Pract. 2011 Oct;94(1):133-9. doi: 10.1016/j.diabres.2011.07.017. Epub 2011 Aug 6.
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Polymicrobial nature of chronic diabetic foot ulcer biofilm infections determined using bacterial tag encoded FLX amplicon pyrosequencing (bTEFAP).采用细菌标签编码的FLX扩增子焦磷酸测序技术（bTEFAP）确定慢性糖尿病足溃疡生物膜感染的多微生物性质。
PLoS One. 2008 Oct 3;3(10):e3326. doi: 10.1371/journal.pone.0003326.
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Microbiology of diabetic foot infections in a teaching hospital in Malaysia: a retrospective study of 194 cases.马来西亚一家教学医院糖尿病足感染的微生物学：194例回顾性研究
J Microbiol Immunol Infect. 2007 Feb;40(1):39-44.
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Bacteriological study of diabetic foot infections.糖尿病足感染的细菌学研究
J Diabetes Complications. 2005 May-Jun;19(3):138-41. doi: 10.1016/j.jdiacomp.2004.06.001.
9
The use of antibiotics in the diabetic foot.抗生素在糖尿病足中的应用。
Am J Surg. 2004 May;187(5A):25S-28S. doi: 10.1016/S0002-9610(03)00300-3.