Petrogiannis Nikos, Chatzovoulou Kalliopi, Filippa Maria, Petrogiannis Savvas, Chatzimeletiou Katerina
IVF Unit, Naval Hospital of Athens, Athens, GRC.
Unit for Human Reproduction, 1st Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Cureus. 2024 Jul 24;16(7):e65281. doi: 10.7759/cureus.65281. eCollection 2024 Jul.
In vitro maturation (IVM) of oocytes represents an assisted reproductive technique that involves the minimal or absence of ovarian stimulation and is beneficial to specific groups of patients. It is based on the collection of immature cumulus-oocyte complexes (COCs) from antral follicles, which are cultured in vitro until they reach the metaphase II (MII) stage. Once maturation is completed, IVM oocytes are normally fertilized, as during a conventional IVF protocol. On the other hand, ovarian rejuvenation through the intraovarian platelet-rich plasma (PRP) injection represents an innovative procedure intended to restore ovarian fertility and development, and it is used to enhance ovarian stimulation outcomes. Here, we report a case of a 47-year-old woman who underwent an assisted reproductive technology cycle (ART) with PRP injection and IVM, which resulted in a successful pregnancy.
卵母细胞的体外成熟（IVM）是一种辅助生殖技术，该技术涉及极少的卵巢刺激或不进行卵巢刺激，对特定患者群体有益。它基于从窦卵泡中采集未成熟的卵丘-卵母细胞复合体（COC），将其在体外培养直至达到中期II（MII）阶段。一旦成熟完成，IVM卵母细胞通常像在传统体外受精方案中一样进行受精。另一方面，通过卵巢内注射富含血小板血浆（PRP）来实现卵巢功能恢复是一种旨在恢复卵巢生育能力和发育的创新程序，用于提高卵巢刺激效果。在此，我们报告一例47岁女性的病例，该女性接受了伴有PRP注射和IVM的辅助生殖技术周期（ART），并成功怀孕。
