Bellut Nicolas, Lutz Claire Manon, Lesnik Maria, Dridi Sophie-Myriam, Aerts Isabelle, Ejeil Anne-Laure
Department of Maxillofacial and Oral Surgery, Saint-Joseph Hospital, Paris, France.
Faculty of Odontology, Department of Oral Surgery, Hôpital Bretonneau AP-HP, Paris, France.
Int J Clin Pediatr Dent. 2024 Feb;17(2):187-190. doi: 10.5005/jp-journals-10005-2723.
Ewing sarcoma (ES), a rare malignancy, comprises whatever the age, 4-15% of all primary bone tumors. It represents 1% of all malignant tumors in children and is the fourth most common bone malignancy after myeloma, osteosarcoma, and chondrosarcoma.
A 12-year-old boy came to the Oral Surgery Department of Bretonneau Hospital referred by his dentist with a rapidly evolving swelling in the left mandibula for 6 weeks, which was initially diagnosed as a facial cellulitis. Cone beam computed tomography (CBCT) showed a poorly defined, expansile, and osteolytic tumor on the left side of the mandible. Clinical and radiographic findings were in favor of an aggressive primitive bone tumor. A mandibular biopsy under general anesthesia was performed in the Department of Surgical Oncology at Institut Curie in Paris, revealing an ES.
Mandibular ES can mimic dental infections when swelling is the main clinical manifestation, which can lead to a delayed diagnosis. A correlation between clinical, radiological, histopathological, and immunohistochemical with cytogenetics is needed to confirm the diagnosis. Moreover, smaller tumors have better survival.Dentists must therefore be aware of the clinical signs of ES in order to quickly refer patients to a specialized department.
Bellut N, Lutz CM, Lesnik M, Ewing's Sarcoma of Mandible: A Case Report with Review of Literature. Int J Clin Pediatr Dent 2024;17(2):187-190.
尤因肉瘤（ES）是一种罕见的恶性肿瘤，在所有原发性骨肿瘤中占4 - 15%，与年龄无关。它占儿童所有恶性肿瘤的1%，是继骨髓瘤、骨肉瘤和软骨肉瘤之后第四常见的骨恶性肿瘤。
一名12岁男孩因左侧下颌骨迅速发展的肿胀6周，由其牙医转诊至布雷托诺医院口腔外科，最初被诊断为面部蜂窝织炎。锥形束计算机断层扫描（CBCT）显示下颌骨左侧有一个边界不清、膨胀性、溶骨性肿瘤。临床和影像学表现支持侵袭性原发性骨肿瘤。在巴黎居里研究所外科肿瘤学部进行了全身麻醉下的下颌骨活检，结果显示为尤因肉瘤。
当下颌骨尤因肉瘤以肿胀为主要临床表现时，可模仿牙齿感染，从而导致诊断延迟。需要临床、放射学、组织病理学、免疫组织化学与细胞遗传学之间的相关性来确诊。此外，较小的肿瘤生存率更高。因此，牙医必须了解尤因肉瘤的临床体征，以便迅速将患者转诊至专科科室。
Bellut N, Lutz CM, Lesnik M, 下颌骨尤因肉瘤：一例报告并文献复习。《国际临床儿科牙科学杂志》2024年；17(2):187 - 190。
