Taylor Amanda, Best Emma J, Walls Tony, Webb Rachel, Bhally Hasan, Bryce Aliya, Chang Cat L, Chen Kevin, Dummer Jack, Epton Michael, Good William, Goodson Jennifer, Grey Corina, Grimwade Kate, Hancox Robert J, Hassan Redzuan Zarool, Hills Thomas, Hotu Sandra, McArthur Colin, Morpeth Susan, Murdoch David R, Pease Fiona, Pylypchuk Romana, Raymond Nigel, Ritchie Stephen, Ryan Debbie, Selak Vanessa, Storer Malina, Williman Jonathan, Wong Conroy, Wright Karen, Maze Michael J
Department of Paediatrics, University of Auckland, Auckland, New Zealand.
Department of Paediatrics, University of Otago, Christchurch, New Zealand.
IJID Reg. 2024 Jul 20;12:100408. doi: 10.1016/j.ijregi.2024.100408. eCollection 2024 Sep.
This multicenter cohort study describes Aotearoa New Zealand children hospitalized during the country's first wave of sustained SARS-CoV-2 transmission, Omicron variant.
Children younger than 16 years, hospitalized for >6 hours with COVID-19 across New Zealand from January to May 2022 were included. Admissions for all Māori and Pacific and every second non-Maori non-Pacific children were selected to support equal explanatory power for ethnic grouping. Attribution of hospital admission, demography, clinical presentation, comorbidity, treatment, and outcome data were collected.
Of 444 hospitalizations of children positive for COVID-19, 292 (65.5%) from 290 children were considered admissions attributable to COVID-19. Of these admissions, 126 (43.4%) were aged under 1; 118 (40.7%), 99 (34.1%), and 87 (30.0%) were children of Māori, Pacific, and non-Maori non-Pacific ethnicity, respectively. Underlying respiratory disease was the most common comorbidity, present in 22 children (7.6%); 16 children (5.5%) were immunosuppressed. Median length of stay was 1 day (interquartile range 0.0-2.0). Four children received antiviral, 69 (24%) antibacterial, and 24 (8%) supplemental oxygen. Although eight children required intensive care, there were no deaths.
Children hospitalized during the first significant wave of SARS-CoV-2 infection in New Zealand presented with a multi-system viral illness and rarely with severe disease.
这项多中心队列研究描述了在新西兰第一波持续的新冠病毒（SARS-CoV-2）奥密克戎变种传播期间住院的儿童情况。
纳入2022年1月至5月在新西兰因新冠病毒感染住院超过6小时的16岁以下儿童。选取所有毛利族和太平洋岛族儿童以及每隔一名非毛利非太平洋岛族儿童的入院病例，以支持对种族分组具有同等的解释力。收集住院原因、人口统计学、临床表现、合并症、治疗及结果数据。
在444例新冠病毒检测呈阳性的儿童住院病例中，来自290名儿童的292例（65.5%）被认为是因新冠病毒感染入院。在这些入院病例中，126例（43.4%）年龄在1岁以下；分别有118例（40.7%）、99例（34.1%）和87例（30.0%）为毛利族、太平洋岛族和非毛利非太平洋岛族儿童。潜在的呼吸系统疾病是最常见的合并症，有22名儿童（7.6%）患有；16名儿童（5.5%）免疫功能低下。住院时间中位数为1天（四分位间距0.0 - 2.0）。4名儿童接受了抗病毒治疗，69名（24%）接受了抗菌治疗，24名（8%）接受了补充氧气治疗。虽然有8名儿童需要重症监护，但无死亡病例。
在新西兰第一波重大新冠病毒感染浪潮期间住院的儿童表现为多系统病毒感染疾病，很少出现严重疾病。
