一名患有三 X 综合征患者的难治性血栓性血小板减少性紫癜
Refractory Thrombotic Thrombocytopenic Purpura in a Patient With Triple X Syndrome.
作者信息
da Rocha Ribas Pedro Arthur, Ghiraldi Julia, Gugelmin Giovanna, Gortz Lucas Wagner, de Carvalho Mauricio, Lenci Marques Gustavo
机构信息
Department of Internal Medicine, Clinical Hospital Complex of the Federal University of Paraná, Curitiba, BRA.
Department of Internal Medicine, School of Medicine, Federal University of Paraná, Curitiba, BRA.
出版信息
Cureus. 2024 Aug 23;16(8):e67631. doi: 10.7759/cureus.67631. eCollection 2024 Aug.
Abstract
Clinical manifestations of triple X syndrome (karyotype 47, XXX) can include autoimmune diseases. We describe the occurrence of acquired thrombotic thrombocytopenic purpura (TTP), an autoimmune condition, refractory to plasmapheresis and rituximab in a patient with triple X syndrome who required vincristine administration for disease remission. To our knowledge, this rare coexistence is the first of its kind reported in Brazil.
摘要
XXX综合征（核型47, XXX）的临床表现可能包括自身免疫性疾病。我们描述了一名XXX综合征患者发生获得性血栓性血小板减少性紫癜（TTP），这是一种自身免疫性疾病，对血浆置换和利妥昔单抗治疗无效，需要使用长春新碱才能使病情缓解。据我们所知，这种罕见的共存情况在巴西尚属首次报道。
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