Yan Dingyuan, Li Zheng, Lee Michelle M S, Zhong Tang Ben, Wang Dong
Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, China.
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research, Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong, 999077, China.
Angew Chem Int Ed Engl. 2024 Dec 16;63(51):e202414259. doi: 10.1002/anie.202414259. Epub 2024 Oct 25.
Pathogenic infectious diseases have persistently posed significant threats to public health. Phototheranostics, which combines the functions of diagnostic imaging and therapy, presents an extremely promising solution to block the spread of pathogens as well as the outbreak of epidemics owing to its merits of a wide-spectrum of activity, high controllability, non-invasiveness, and difficult to acquire resistance. Among multifarious phototheranostic agents, second near-infrared (NIR-II, 1000-1700 nm) aggregation-induced emission luminogens (AIEgens) are notable by virtue of their deep penetration depth, excellent biocompatibility, balanced radiative and nonradiative decay and aggregation-enhanced theranostic performance, making them an ideal option for combating pathogens. This minireview provides a systematical summary of the latest advancements in NIR-II AIEgens with emphasis on the molecular design and nanoplatform formulation to fulfill high-efficiency in treating bacterial and viral pathogens, classified by disease models. Then, the current challenges, potential opportunities, and future research directions are presented to facilitate the further progress of this emerging field.
致病性传染病一直对公众健康构成重大威胁。光诊疗学结合了诊断成像和治疗功能，由于其具有广谱活性、高可控性、非侵入性以及难以产生耐药性等优点，为阻止病原体传播和疫情爆发提供了极具前景的解决方案。在各种光诊疗剂中，第二近红外（NIR-II，1000 - 1700 nm）聚集诱导发光 luminogens（AIEgens）因其穿透深度深、生物相容性好、辐射和非辐射衰减平衡以及聚集增强的诊疗性能而备受关注，使其成为对抗病原体的理想选择。本综述系统总结了 NIR-II AIEgens 的最新进展，重点介绍了通过疾病模型分类的、用于高效治疗细菌和病毒病原体的分子设计和纳米平台配方。然后，阐述了当前面临的挑战、潜在机遇以及未来的研究方向，以推动这一新兴领域的进一步发展。
