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微血管减压术后听力损失的预测列线图。

Predictive nomogram for hearing deficits after microvascular decompression treatment.

机构信息

Department of Neurosurgery, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), No.1 Jiaozhou Road, Qingdao, Shandong Province, 266011, P.R. China.

Department of Neurosurgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, 1665 KongJiang Rd, Shanghai, 200092, P. R. China.

出版信息

Neurosurg Rev. 2024 Aug 26;47(1):481. doi: 10.1007/s10143-024-02716-2.

Abstract

We explored the impact of brainstem auditory evoked potentials monitoring, as well as anatomical characteristics, in relation to their influence on hearing deficits. A total of 851 patients diagnosed with idiopathic hemifacial spasm underwent microvascular decompression treatment were recruited in our study. A nomogram was developed based on the regression analysis. Nomogram performance was evaluated through receiver operating characteristic (ROC), decision curve analyses and calibration curve. The rate of positive wave V change was also higher in the hearing deficit group (71.8% vs no hearing deficit group, p < 0.001). Furthermore, greater retraction depth (0.78 ± 0.25 cm vs 0.55 ± 0.12 cm, p < 0.001), duration (74.43 ± 15.74 min vs 55.71 ± 7.01 min, p < 0.001) and retraction distance (4.38 ± 0.38 cm vs 4.17 ± 0.24 cm, p = 0.001) were evident in the hearing deficit patients. Multivariate logistic regression showed that positive wave V change (OR 5.43), greater retraction depth (OR 55.57) and longer retraction duration (OR 1.14) emerged as significant independent predictors of postoperative hearing deficit. The external validation cohort exhibited a favorable discrimination with an AUC of 0.88. The calibration curves further confirmed the reliability of the predicted outcome in relation to the observed outcome in the external validation cohort (p = 0.89). The decision curves demonstrated that the nomogram outperformed the All or None scheme when the threshold probability ranged from > 2% to < 60% in the external validation cohort. We constructed a nomogram, including wave V, retraction depth, and retraction duration, which can effectively predict the occurrence of hearing deficits and has good clinical applicability.

摘要

我们探讨了脑干听觉诱发电位监测以及解剖学特征对听力缺陷的影响。本研究共纳入 851 例特发性面肌痉挛患者,均行微血管减压术治疗。基于回归分析建立了列线图。通过受试者工作特征(ROC)曲线、决策曲线分析和校准曲线评估列线图性能。听力缺陷组阳性波 V 改变率也更高(71.8% vs 无听力缺陷组,p<0.001)。此外,听力缺陷组的回缩深度更大(0.78±0.25 cm vs 0.55±0.12 cm,p<0.001)、持续时间更长(74.43±15.74 min vs 55.71±7.01 min,p<0.001)和回缩距离更长(4.38±0.38 cm vs 4.17±0.24 cm,p=0.001)。多变量逻辑回归显示阳性波 V 改变(OR 5.43)、回缩深度更大(OR 55.57)和回缩持续时间更长(OR 1.14)是术后听力缺陷的显著独立预测因子。外部验证队列显示出良好的区分度,AUC 为 0.88。校准曲线进一步证实了外部验证队列中预测结果与观察结果的可靠性(p=0.89)。决策曲线表明,在外部验证队列中,阈值概率范围为>2%至<60%时,列线图优于“全有或全无”方案。我们构建了一个列线图,包括波 V、回缩深度和回缩持续时间,可有效预测听力缺陷的发生,具有良好的临床适用性。

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