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通过脉冲动脉自旋标记推进 7T 灌注成像：使用并行传输线圈提高标记稳健性和时间 SNR。

Advancing 7T perfusion imaging by pulsed arterial spin labeling: Using a parallel transmit coil for enhanced labeling robustness and temporal SNR.

机构信息

Spinoza Centre for Neuroimaging, Netherlands Academy for Arts and Sciences, Amsterdam, Netherlands.

Computational Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience, Amsterdam, Netherlands.

出版信息

PLoS One. 2024 Aug 26;19(8):e0309204. doi: 10.1371/journal.pone.0309204. eCollection 2024.

DOI:10.1371/journal.pone.0309204
PMID:39186519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11346640/
Abstract

Non-invasive perfusion imaging by Arterial spin labeling (ASL) can be advantageous at Ultra-high field (UHF) MRI, since the image SNR and the T1 relaxation time both increase with the static field. However, ASL implementation, especially at 7T, is not trivial. Especially for ASL, UHF MRI comes with many challenges, mainly due to B1+ inhomogeneities. This study aimed to investigate the effects of different transmit coil configurations on perfusion-weighted imaging at 7T using a flow-sensitive alternating inversion recovery (FAIR) technique with time-resolved frequency offset corrected inversion (TR-FOCI) pulses for labeling and background suppression. We conducted a performance comparison between a parallel transmit (pTx) system equipped with 32 receive (Rx) and 8 transmit (Tx) channels and a standard setup with 32Rx and 2Tx channels. Our findings demonstrate that the pTx system, characterized by a more homogeneous B1 transmit field, resulted in a significantly higher contrast-to-noise ratio, temporal signal-to-noise ratio, and lower coefficient of variance (CoV) than the standard 2Tx setup. Additionally, both setups demonstrated comparable capabilities for functional mapping of the hand region in the motor cortex, achieving reliable results within a short acquisition time of approximately 5 minutes.

摘要

动脉自旋标记（ASL）的无创灌注成像是超高频（UHF）MRI 的优势，因为图像信噪比和 T1 弛豫时间都随静磁场增加而增加。然而，ASL 的实现，特别是在 7T 下，并不简单。特别是对于 ASL，UHF MRI 带来了许多挑战，主要是由于 B1 不均匀性。本研究旨在使用带时间分辨频率偏移校正反转（TR-FOCI）脉冲的流动敏感交替反转恢复（FAIR）技术，研究不同发射线圈配置对 7T 灌注加权成像的影响，用于标记和背景抑制。我们对配备 32 个接收（Rx）和 8 个发射（Tx）通道的并行发射（pTx）系统和具有 32Rx 和 2Tx 通道的标准设置进行了性能比较。我们的研究结果表明，pTx 系统的 B1 发射场更均匀，与标准的 2Tx 系统相比，对比度噪声比、时间信号噪声比显著提高，变异系数（CoV）更低。此外，这两种设置在手运动皮层的功能映射方面都表现出了相当的能力，在大约 5 分钟的短采集时间内获得了可靠的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/d6abe7e4a0d8/pone.0309204.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/6f6a8ab37aa1/pone.0309204.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/847aa997cb82/pone.0309204.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/06fc82f41901/pone.0309204.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/024d664351c0/pone.0309204.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/5ec47c0277aa/pone.0309204.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/a75393b21c58/pone.0309204.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/eefb027d34eb/pone.0309204.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/c2b130438fc2/pone.0309204.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/d6abe7e4a0d8/pone.0309204.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/6f6a8ab37aa1/pone.0309204.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/847aa997cb82/pone.0309204.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/06fc82f41901/pone.0309204.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/024d664351c0/pone.0309204.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/5ec47c0277aa/pone.0309204.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/a75393b21c58/pone.0309204.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/eefb027d34eb/pone.0309204.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/c2b130438fc2/pone.0309204.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4aff/11346640/d6abe7e4a0d8/pone.0309204.g009.jpg

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