St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia; Department of Medicine, Eastern Hill Precinct, Melbourne Medical School, University of Melbourne, Fitzroy, Victoria, Australia.
St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia; Department of Medicine, Eastern Hill Precinct, Melbourne Medical School, University of Melbourne, Fitzroy, Victoria, Australia.
Exp Hematol. 2024 Nov;139:104621. doi: 10.1016/j.exphem.2024.104621. Epub 2024 Aug 24.
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2, respectively. A-to-I editing by ADAR1 is also critical in regulating hematopoiesis. This review will focus on the role of A-to-I RNA editing and ADAR enzymes, particularly ADAR1, during normal hematopoiesis in humans and mice. Furthermore, we will discuss Adar1 mouse models that have been developed to understand the contribution of ADAR1 to hematopoiesis and its role in innate immune pathways.
腺嘌呤到肌苷（A-to-I）RNA 编辑在调节正常发育和内稳态方面发挥着重要作用。该过程由腺嘌呤脱氨酶作用于 RNA（ADAR）家族蛋白催化。A-to-I 编辑调节的最被理解的生物学过程是先天免疫和神经发育，分别归因于 ADAR1 和 ADAR2。ADAR1 的 A-to-I 编辑在调节造血中也至关重要。本综述将重点介绍 A-to-I RNA 编辑和 ADAR 酶，特别是 ADAR1，在人类和小鼠正常造血中的作用。此外，我们将讨论为了解 ADAR1 对造血的贡献及其在先天免疫途径中的作用而开发的 Adar1 小鼠模型。
