Key Laboratory for Early Diagnosis and Biotherapy of Malignant Tumors in Children and Women, Dalian Women and Children's Medical Group, Dalian, Liaoning, China.
The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
J Affect Disord. 2024 Nov 15;365:606-613. doi: 10.1016/j.jad.2024.08.160. Epub 2024 Aug 24.
Psychiatric disorders, including attention-deficit hyperactivity disorder (ADHD), depression, anxiety disorders, and dementia, manifest differently across life stages, impacting cognitive, emotional, and behavioral health. Understanding the causal relationships between various types of physical activity and these disorders is crucial for developing targeted interventions.
The summary level data from GWAS was utilized to conduct a two-sample Mendelian Randomization (MR) analysis. We assessed the potential causal relationships between different types of physical activity including light do it yourself (DIY) activities, heavy DIY activities, strenuous sports, and aerobic exercises/other exercises and the prevalence of psychiatric disorders (ADHD, depression, anxiety disorders, and dementia) across different life stages.
The MR analysis showed no causal relationship between light DIY activities and any of the psychiatric disorders studied. Heavy DIY activities showed a significant negative association with anxiety disorders but no links with ADHD, depression, or dementia. Strenuous sports did not demonstrate any causal relationship with the psychiatric disorders examined. Aerobic exercises were notably correlated with a reduced risk of depression, although no significant associations were found with ADHD, anxiety disorders, or dementia.
The findings indicate that heavy DIY activities might contribute to reducing anxiety disorders, while aerobic exercises potentially lower the risk of depression. These results emphasize the potential benefits of promoting specific types of physical activity to improve mental health outcomes across different life stages. Future research could further investigate the mechanisms underlying these relationships and consider diverse populations and objective measures of physical activity.
精神障碍，包括注意力缺陷多动障碍（ADHD）、抑郁症、焦虑症和痴呆症，在不同的生命阶段表现不同，影响认知、情感和行为健康。了解各种类型的身体活动与这些障碍之间的因果关系对于制定有针对性的干预措施至关重要。
使用 GWAS 的汇总水平数据进行两样本 Mendelian Randomization（MR）分析。我们评估了不同类型的身体活动（包括轻度 DIY 活动、重度 DIY 活动、剧烈运动和有氧运动/其他运动）与精神障碍（ADHD、抑郁症、焦虑症和痴呆症）在不同生命阶段的患病率之间的潜在因果关系。
MR 分析表明，轻度 DIY 活动与研究的任何精神障碍之间没有因果关系。重度 DIY 活动与焦虑症呈显著负相关，但与 ADHD、抑郁症或痴呆症无关。剧烈运动与所检查的精神障碍之间没有任何因果关系。有氧运动与降低抑郁症风险显著相关，尽管与 ADHD、焦虑症或痴呆症没有显著关联。
研究结果表明，重度 DIY 活动可能有助于减少焦虑症，而有氧运动可能降低抑郁症的风险。这些结果强调了促进特定类型的身体活动以改善不同生命阶段心理健康结果的潜在益处。未来的研究可以进一步探讨这些关系背后的机制，并考虑不同人群和身体活动的客观衡量标准。
