Department of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Department of Nuclear Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Neuroimage. 2024 Sep;298:120814. doi: 10.1016/j.neuroimage.2024.120814. Epub 2024 Aug 24.
Sleep disturbance is associated with the development of neurodegenerative disease. We aimed to address the effects of sleep quality on brain glucose metabolism measured by F-Fl uorodeoxyglucose (F-FDG) positron emission tomography (PET) in healthy middle-aged adults. A total of 378 healthy men (mean age: 42.8±3.6 years) were included in this study. Participants underwent brain F-FDG PET and completed the Korean version of the Pittsburgh Sleep Quality Index (PSQI-K). Additionally, anthropometric measurements were obtained. PETs were spatially normalized to MNI space using PET templates from SPM5 with PMOD. The Automated Anatomical Labeling 2 atlas was used to define regions of interest (ROIs). The mean uptake of each ROI was scaled to the mean of the global cortical uptake of each individual and defined as the standardized uptake value ratio (SUVR). After the logarithmic transformation of the regional SUVR, the effects of the PSQI-K on the regional SUVR were investigated using Bayesian hierarchical modeling. Brain glucose metabolism of the posterior cingulate, precuneus, and thalamus showed a negative association with total PSQI-K scores in the Bayesian model ROI-based analysis. Voxel-based analysis using statistical parametric mapping revealed a negative association between the total PSQI-K scores and brain glucose metabolism of the precuneus, postcentral gyrus, posterior cingulate, and thalamus. Poor sleep quality is negatively associated with brain glucose metabolism in the precuneus, posterior cingulate, and thalamus. Therefore, the importance of sleep should not be overlooked, even in healthy middle-aged adults.
睡眠障碍与神经退行性疾病的发展有关。我们旨在研究健康中年人群中睡眠质量对脑葡萄糖代谢的影响，采用 F-F 氟脱氧葡萄糖（F-FDG）正电子发射断层扫描（PET）进行测量。共有 378 名健康男性（平均年龄：42.8±3.6 岁）纳入本研究。参与者接受了脑部 F-FDG PET 检查，并完成了韩国版匹兹堡睡眠质量指数（PSQI-K）。此外，还进行了人体测量。通过 SPM5 中的 PET 模板和 PMOD 将 PET 进行空间归一化到 MNI 空间。使用自动解剖标记 2 图谱定义感兴趣区（ROI）。将每个 ROI 的平均摄取量标准化为每个个体的皮质总体摄取平均值，并定义为标准化摄取比值（SUVr）。对区域 SUVr 进行对数转换后，使用贝叶斯分层模型研究 PSQI-K 对区域 SUVr 的影响。在后扣带回、楔前叶和丘脑的 ROI 基于分析的脑葡萄糖代谢与总 PSQI-K 评分呈负相关。使用统计参数映射的基于体素分析显示，总 PSQI-K 评分与楔前叶、中央后回、后扣带回和丘脑的脑葡萄糖代谢呈负相关。睡眠质量差与楔前叶、后扣带回和丘脑的脑葡萄糖代谢呈负相关。因此，即使在健康中年人群中，也不应忽视睡眠的重要性。
